Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19

Study Group*, ACTIV-3/TICO; Barkauskas, Christina; Mylonakis, Eleftherios; Poulakou, Garyfallia; Edward Young, Barnaby; M. Vock, David; Siegel, Lianne; Engen, Nicole; Grandits, Greg; Mosaly, Nilima; M. Vekstein, Andrew; Rogers, Ralph; Shehadeh, Fadi; Kaczynski, Matthew; K. Mylona, Evangelia; N. Syrigos, Konstantinos; Rapti, Vasiliki; Chien Lye, David; Shiau Hui, Diong; Leither, Lindsay; U. Knowlton, Kirk; K. Jain, Mamta; Marines-Price, Rubria; Osuji, Alice; Scott Overcash, J.; Kalomenidis, Ioannis; Barmparessou, Zafeiria; R. Waters, Michael; Zepeda, Karla; Chen, Peter; Torbati, Sam; Kiweewa, Francis; Sebudde, Nicholus; Almasri, Eyad; Hughes, Alyssa; Bhagani, Sanjay; Rodger, Alison; Sandkovsky, Uriel; Gottlieb, Robert; Eriobu, Nnakelu; W. Trautner, Barbara; Menon, Vidya; Lutaakome, Joseph; Matthay, Michael; A. Robinson, Philip; Protopapas, Konstantinos; Koulouris, Nikolaos; Kimuli, Ivan; Baduashvili, Amiran; L. Braun, Dominique; F. Günthard, Huldrych; Ramachandruni, Srikanth; Kidega, Robert; Kim, Kami; Hatlen, Timothy; Phillips, Andrew; D. Murray, Daniel; Ø. Jensen, Tomas; L. Padilla, María; X. Accardi, Evan; Shaw-Saliba, Katy; Dewar, Robin; Teitelbaum, Marc; Natarajan, Ven; Laverdure, Sylvain; C. Highbarger, Helene; Tauseef Rehman, M.; Vogel, Susan; Vallée, David; Crew, Page; Atri, Negin; Schechner, Adam; Pett, Sarah; Hudson, Fleur; Badrock, Jonathan; Touloumi, Giota; M. Brown, Samuel; H. Self, Wesley; M. North, Crystal; A. Ginde, Adit; C. Chang, Christina; D. Kelleher, Anthony; Nagy-Agren, Stephanie; Vasudeva, Shikha; P. Looney, David; Nguyen, Hien; Sánchez, Adriana; Weintrob, Amy; Grund, Birgit; Sharma, Shweta; Reilly, Cavan; Paredes, Roger; Bednarska, Agnieszka; P. Gerry, Norman; G. Babiker, Abdel; J. Davey, Victoria; C. Gelijns, Annetine; S. Higgs, Elizabeth; Kan, Virginia; Matthews, Gail; Taylor Thompson, B.; Legenne, Philippe; Chandra, Richa; Clifford Lane, H.; D. Neaton, James; Lundgren, Jens; Barkauskas, Christina; Mylonakis, Eleftherios; Poulakou, Garyfallia; Edward Young, Barnaby; M. Vock, David; Siegel, Lianne; Engen, Nicole; Grandits, Greg; Mosaly, Nilima; M. Vekstein, Andrew; Rogers, Ralph; Shehadeh, Fadi; Kaczynski, Matthew; K. Mylona, Evangelia; N. Syrigos, Konstantinos; Rapti, Vasiliki; Chien Lye, David; Shiau Hui, Diong; Leither, Lindsay; U. Knowlton, Kirk; K. Jain, Mamta; Marines-Price, Rubria; Osuji, Alice; Scott Overcash, J.; Kalomenidis, Ioannis; Barmparessou, Zafeiria; R. Waters, Michael; Zepeda, Karla; Chen, Peter; Torbati, Sam; Kiweewa, Francis; Sebudde, Nicholus; Almasri, Eyad; Hughes, Alyssa; Bhagani, Sanjay; Rodger, Alison; Sandkovsky, Uriel; Gottlieb, Robert; Eriobu, Nnakelu; W. Trautner, Barbara; Menon, Vidya; Lutaakome, Joseph; Matthay, Michael; A. Robinson, Philip; Protopapas, Konstantinos; Koulouris, Nikolaos; Kimuli, Ivan; Baduashvili, Amiran; L. Braun, Dominique; F. Günthard, Huldrych; Ramachandruni, Srikanth; Kidega, Robert; Kim, Kami; Hatlen, Timothy; Phillips, Andrew; D. Murray, Daniel; Ø. Jensen, Tomas; L. Padilla, María; X. Accardi, Evan; Shaw-Saliba, Katy; Dewar, Robin; Teitelbaum, Marc; Natarajan, Ven; Laverdure, Sylvain; C. Highbarger, Helene; Tauseef Rehman, M.; Vogel, Susan; Vallée, David; Crew, Page; Atri, Negin; Schechner, Adam; Pett, Sarah; Hudson, Fleur; Badrock, Jonathan; Touloumi, Giota; M. Brown, Samuel; H. Self, Wesley; M. North, Crystal; A. Ginde, Adit; C. Chang, Christina; D. Kelleher, Anthony; Nagy-Agren, Stephanie; Vasudeva, Shikha; P. Looney, David; Nguyen, Hien; Sánchez, Adriana; Weintrob, Amy; Grund, Birgit; Sharma, Shweta; Reilly, Cavan; Paredes, Roger; Bednarska, Agnieszka; P. Gerry, Norman; G. Babiker, Abdel; J. Davey, Victoria; C. Gelijns, Annetine; S. Higgs, Elizabeth; Kan, Virginia; Matthews, Gail; Taylor Thompson, B.; Legenne, Philippe; Chandra, Richa; Clifford Lane, H.; D. Neaton, James; Lundgren, Jens; Sahner, David; Tierney, J.W.; Herpin, Betsey; Smolskis, Mary; A McKay, Laura; Cahill, Kelly; Sardana, Ratna; Segal Raim, Sharon; Hensely, Lisa; Lorenzo, Joshua; Mock, Rebecca; Zuckerman, Judith; D. Miller, Mark; Chung, Lucy; Kang, Nayon; J. Adam, Stacey; Read, Sarah; Draghia‐Akli, Ruxandra; Carlsen, Amy; Carter, Anita; Denning, Eileen; DuChêne, Alain; Eckroth, Kate; Frase, Alex; Gandits, Greg; Harrison, Merrie; Kaiser, Payton; S. Koopmeiners, Joseph; Meger, Sue; A. Murray, Thomas; Quan, Kien; Fun Quan, Siu; Thompson, Greg; Walski, Jamie; Wentworth, Deborah; J. Moskowitz, Alan; Bagiella, Emilia; Moquete, Ellen; O’Sullivan, Karen; E. Marks, Mary; Kinzel, Emily; Burris, Sarah; Bedoya, Gabriela; Gupta, Lola; Overbey, Jessica; L. Padillia, Maria; Santos, Milerva; A. Gillinov, Marc; A. Miller, Marissa; C. Taddei‐Peters, Wendy; N. Fenton, Kathleen; Mack, M.; Berhe, Mezgebe; Haley, Clinton; Dishner, Emma; Bettacchi, Christopher; Golden, Kevin; Duhaime, Erin; Ryan, Madison; Burris, Sarah; Tallmadge, Catherine; Estrada, Lorie; Jones, Felecia; Villa, Samatha; Wang, Samatha; Robert, Raven; Coleman, Tanquinisha; Clariday, Laura; Baker, Rebecca; Hurutado-Rodriguez, Mariana; Iram, Nazia; Fresnedo, Michelle; Davis, Allyson; Leonard, Kiara; Ramierez, Noelia; Thammavong, Jon; Duque, Krizia; Turner, Emma; L. Fisher, T.; Robinson, Dianna; Ransom, Desirae; Maldonado, Nicholas; Lusk, Erica; Killian, Aaron; Palacious, Adriana; Solis, Edilia; Jerrow, Janet; Watts, Matthew; Whitacre, Heather; Cothran, Elizabeth; K. Smith, Peter; R. Ko, Emily; R. Dreyer, Grace; Stafford, Neil; Brooks, Megan; Der, Tatyana; Witte, Marie; Gamarallage, Ruwan; Franzone, John; Ivey, Noel; Lumsden, Rebecca; Mourad, Ahmaad; L Holland, Thomas; Motta, Mary; Lane, Kathleen; M. McGowan, Lauren; Stout, Jennifer; Aloor, Heather; M. Bragg, Kennesha; Toledo, Barvina; McLendon-Arvik, Beth; Bussadori, Barbara; Hollister, Beth; Griffin, Michelle; M. Giangiacomo, Dana; Martínez Rodríguez, Vicente; E. Parrino, Patrick; M. Spindel, Stephen; Bansal, Aditya; Baumgarten, Katherine; Hand, Johnathan; J. Vonderhaar, Derek; D. Nossaman, Bobby; Laudun, Sylvia; Ames, DeAnna; Broussard, Shane; Hernandez, Nilmo; Isaac, Geralyn; Dinh, Huan; Zheng, Yiling; Tran, Sonny; McDaniel, Hunter; Crovetto, Nicolle; C. Perin, Emerson; Costello, Briana; Manian, Prasad; Rizwan Sohail, M.; Postalian, Alexander; Hinsu, Punit; Watson, Carolyn; Chen, James; Fink, Melyssa; Sturgis, Lydia; Kim, Walker; Mahon, Kim; Parenti, Jennifer; Kappenman, Casey; Knight, Aryn; M. Sturek, Jeffrey; Barros, Andrew; B. Enfield, Kyle; Kadl, Alexandra; J. Green, China; M. Simon, Rachel; Fox, Ashley; J Thornton, Kara; Adams, Amy; H. Traverse, Jay; S. Rhame, Frank; Huelster, Joshua; Kethireddy, Rajesh; Salamanca, Julianne; Majeski, Christine; Skelton, Paige; Zarambo, Maria; Sarafolean, Andrea; F. Oldmixon, Cathryn; Ringwood, Nancy; Muzikansky, Ariela; P. Morse, Richard; G. Brower, Roy; A. Reineck, Lora; R. Aggarwal, Neil; Bienstock, Karen; Steingrub, Jay; Hou, Peter; S. Steingrub, Jay; Tidswell, Mark; Kozikowski, Lori-Ann; Kardos, Cynthia; DeSouza, Leslie; Romain, Sarah; Talmor, Daniel; I. Shapiro, Nathan; Andromidas, Konstantinos; Banner‐Goodspeed, Valerie; Bolstad, Michael; L. Boyle, Katherine; Cabrera, Payton; deVilla, Arnaldo; C. Ellis, Joshua; Grafals, Ana; Hayes, Sharon; Higgins, Conor; Kurt, Lisa; Kurtzman, Nicholas; Redman, Kimberly; Rosseto, Elinita; Scaffidi, Douglas; I. Shapiro, Nathan; Talmor, Daniel; R. Filbin, Michael; A. Hibbert, Kathryn; A. Parry, Blair; Margolin, Justin; Hillis, Brooklynn; Hamer, Rhonda; E. Jones, Alan; Galbraith, James; Nandi, Utsav; Hendey, Gregory; A. Matthay, Michael; N. Kangelaris, Kirsten; Ashktorab, Kimia; Gropper, Rachel; Agrawal, Anika; Almasri, Eyad; Fayed, Mohamed; Hubel, Kinsley; L. Garcia, Rebekah; Lim, George; Y. Chang, Steven; Hendey, Gregory; Lin, Michael; Vargas, Julia; Sihota, Hena; M. Beutler, Rebecca; J. Rogers, Angela; G. Wilson, Jennifer; Vojnik, Rosemary; Pérez, Cynthia; H. McDowell, Jordan; E. Albertson, Timothy; Hardy, Erin; W. Harper, Richart; Moss, M.A.; A. Ginde, Adit; Chauhan, Lakshmi; J. Douin, David; Martinez, Flora; Finck, Lani; Bastman, Jill; C. Hyzy, Robert; K. Park, Pauline; C. Hyzy, Robert; K. Park, Pauline; Nelson, Kristine; Mcsparron, J.I.; Co, Ivan; R. Wang, Bonnie; Jimenez, José; Sullins, Barbara; Olbrich, Norman; N. Gong, Michelle; D. Richardson, Lynne; N. Gong, Michelle; Nair, Rahul; López, Brenda; Amosu, Omowunmi; Tzehaie, Hiwet; Nkemdirim, William; Boujid, Sabah; Mosier, Jarrod; Hypes, Cameron; Salvagio Campbell, Elizabeth; Bixby, Billie; Gilson, Boris; Lopez, Anitza; Duncan Hite, R.; E. 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Jensen, Tomas; Lindegaard Madsen, Birgitte; Ingemann Pedersen, Thomas; Barrella Harboe, Zitta; Thorup Røge, Birgit; Michael Hansen, Thomas; Kanstrup Glesner, Matilde; Valborg Løfberg, Sandra; Denize Nielsen, Ariella; Nielsen, Henrik; Krog Thisted, Rikke; Toft Petersen, Kristine; Ruwald Juhl, Maria; Podlekareva, Daria; Johnsen, Stine; Wiese, Lothar; Surland Knudsen, Lene; Expósito, Maria; Badillo, José; Martínez, Ana; Abad, Elena; Chamorro, Ana; Mateu, Lourdes; España, Sergio; Constanza Lucero, Maria; Ramón Santos, José; Lladós, Gemma; Lopez, Cristina; Carabias, Lydia; Fernández‐Cruz, Eduardo; Di Natale, Marisa; Padure, Sergiu; Gomez, Jimena; Ausín, Cristina; Cervilla, Eva; Balastegui, Héctor; Rodríguez Sáinz, Carmen; Lopez, Paco; Escobar, Mariam; Balerdi, Leire; Legarda, Almudena; Roldán, Montserrat; Letona, Laura; Muñóz, José; Ramón Arribas, José; Montejano Sánchez, Rocio; Díaz‐Pollán, Beatriz; Stewart, Stefan; García-García, Irene; M. Borobia, Alberto; Estrada, Vicente; Cabello, Noemí; Nuñez-Orantos, M.J.; Sagastagoitia, Íñigo; Homen, J.R.; Orviz, Eva; Sánchez Montalvá, Adrián; Espinosa‐Pereiro, Juan; Bosch‐Nicolau, Pau; Salvador, Fernando; Luís Morales‐Rull, José; Maria Moreno Pena, Anna; Acosta, Cristina; Solé-Felip, Cristina; West, Emily; M’Rabeth-Bensalah, Khadija; L. Eichinger, Mareile; Grüttner-Durmaz, Manuela; Grube, Christina; Zink, Veronika; Goes, Josefine; Tsertsvadze, Tengiz; Abutidze, Akaki; Chkhartishvili, Nikoloz; Metchurtchlishvili, Revaz; Endeladze, Marina; Paciorek, Marcin; Bursa, Dominik; Krogulec, Dominika; Pulik, Piotr; Ignatowska, Anna; Fishchuk, Roman; Kobrynska, Olena; Levandovska, Khrystyna; Kirieieva, Ivanna; Kuziuk, Mykhailo; N. Polizzotto, Mark; L. Carey, Catherine; J. Dharan, Nila; Hough, Sally; Virachit, Sophie; Davidson, Sarah; J. Bice, Daniel; Ognenovska, Katherine; Cabrera, Gesalit; Flynn, Ruth; Ying Chia, Po; Hong Lee, Tau; J. Lin, Ray; Wei Xiang Ong, Sean; Hon Puah, Ser; Wen Yeo, Tsin; Ongko, Juwinda; Ping Yeo, He; Kwaghe, Vivian; Zaiyad, Habib; Idoko, Godwin; Uche, Blessing; Selvamuthu, Poongulali; Kumarasamy, Nagalingeswaran; Ester Beulah, Faith; Govindarajan, Narayan; Mariyappan, Kowsalya; H. Losso, Marcelo; Abela, Cecilia; Moretto, Renzo; G. Belloc, Carlos; Ludueña, Jael; Amar, Josefina; H. Losso, Marcelo; Toibaro, Javier; Moreno Macias, Laura; Fernandez, Lucia; S. Frare, Pablo; Chaio, Sebastián; Pachioli, Valeria; M. Timpano, Stella; del Lujan Sanchez, Marisa; de Paz Sierra, Mariana; Stanek, Vanina; Belloso, Waldo; L. Cilenti, Flavia; Valentini, Ricardo; E. Stryjewski, Martín; Locatelli, Nicolas; C. Soler Riera, Maria; Salgado, Clara; Baeck, Inés; Di Castelnuovo, Valentina; M. Zarza, Stella; Parmar, Mahesh; L. Goodman, Anna; Gregory, Adam; J. 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Stumpp, Michael; Gonçalves, Susana; Ramanathan, Krishnan; Baseler, Beth; Preston Holley, H.; Jankelevich, Shirley; Adams, Amy; Becker, Nancy; Dolney, Suzanne; Hissey, Debbie; Simpson, Shelly; Ha Kim, Mi; Beeler, Joy; Harmon, Liam; Asomah, Mabel; Jato, Yvonne; Stottlemyer, April; Tang, Olivia; Vanderpuye, Sharon; Yeon, Lindsey; Buehn, Molly; Eccard-Koons, Vanessa; Frary, Sadie; MacDonald, Leah; Cash, Jennifer; Hoopengardner, Lisa; Linton, Jessica; Schaffhauser, Marylu; Nelson, Michaela; Spinelli-Nadzam, Mary; Proffitt, Calvin; S. Lee, Christopher; Engel, Theresa; Fontaine, Laura; Osborne, Cody; Hohn, Matt; Galcik, Michael; Thompson, DeeDee; Chang, Weizhong; T. Sherman, Brad; Rupert, Adam; Baseler, Michael; Lallemand, Perrine; Imamichi, Tomozumi; Paudel, Sharada; Cook, Kyndal; Haupt, Kendra; Highbarger, Jeroen; Hazen, Allison; Badralmaa, Yunden; E. Smith, Kenneth; Patel, Bhakti; Kubernac, Robert; L. Hoover, Marie; Brown, Craig; DuChateau, Nadine; Ellis, Sadie; Flosi, Adam; Fox, Lisa; Johnson, Les; Nelson, Rich; Stojanović, Jelena; Treagus, Amy; Wenner, Christine; Williams, Richard

doi:10.7326/m22-1503

Public

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19

Published in Annals of Internal Medicine • Aug 8, 2022

Authors:

ACTIV-3/TICO Study Group*

Christina Barkauskas

Eleftherios Mylonakis

Abstract

BACKGROUND: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection. OBJECTIVE: To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients ...

Subject

Medicine

Coronavirus disease 2019 (COVID-19)

2019-20 coronavirus outbreak

Research Assistant

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