Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Hosomi, Koji; Saito, Mayu; Park, Jonguk; Murakami, Haruka; Shibata, Naoko; Ando, Masahiro; Nagatake, Takahiro; Konishi, Kana; Ohno, Harumi; Tanisawa, Kumpei; Mohsen, Attayeb; Chen, Yi-An; Kawashima, Hitoshi; Natsume‐Kitatani, Yayoi; Oka, Yoshimasa; Shimizu, Hidenori; Furuta, Mari; Tojima, Yoko; Sawane, Kento; Saika, Azusa; Kondo, Saki; Yonejima, Yasunori; Takeyama, Haruko; Matsutani, Akira; Mizuguchi, Kenji; Miyachi, Motohiko; Kunisawa, Jun

doi:10.1038/s41467-022-32015-7

Public

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Published in Nature Communications • Aug 18, 2022

Authors:

Koji Hosomi

Mayu Saito

Jonguk Park

Abstract

The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration ...

Subject

Gut flora

Type 2 diabetes

Obesity

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