Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

Rafat, Mehrdad; Jabbarvand, Mahmoud; Sharma, Namrata; Xeroudaki, Maria; Tabe, Shideh; Omrani, Raha; Thangavelu, Muthukumar; Mukwaya, Anthony; Fagerholm, Per; Lennikov, Anton; Askarizadeh, Farshad; Lagali, Neil

doi:10.1038/s41587-022-01408-w

Public

Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

Published in Nature Biotechnology • Aug 11, 2022

Authors:

Mehrdad Rafat

Mahmoud Jabbarvand

Namrata Sharma

Abstract

Visual impairment from corneal stromal disease affects millions worldwide. We describe a cell-free engineered corneal tissue, bioengineered porcine construct, double crosslinked (BPCDX) and a minimally invasive surgical method for its implantation. In a pilot feasibility study in India and Iran (cli...

Subject

Keratoconus

Contact lens

Medicine

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