Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

R. Shin, Hijai; Rose Citron, Y.; Wang, Lei; Tribouillard, Laura; S. Goul, Claire; Stipp, Robin; Sugasawa, Yusuke; Jain, Aakriti; Samson, Nolwenn; Lim, Chun-Yan; B. Davis, Oliver; Castaneda-Carpio, David; Qian, Mingxing; K. Nomura, Daniel; M. Perera, Rushika; Park, Eunyong; F. Covey, Douglas; Laplante, Mathieu; S. Evers, Alex; Zoncu, Roberto

doi:10.1126/science.abg6621

Public

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

Published in Science • Aug 25, 2022

Authors:

Hijai R. Shin

Y. Rose Citron

Lei Wang

Abstract

Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling (LYCHOS, previously annotated as G protein-coupled receptor 155), a multidomain transme...

Subject

mTORC1

GTPase

Cell biology

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