Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT

A. Bohula, Erin; D. Berg, David; S. Lopes, Mathew; M. Connors, Jean; Babar, Ijlal; F. Barnett, Christopher; Chaudhry, Sunit‐Preet; Chopra, Amit; Ginete, Wilson; H. Ieong, Michael; N. Katz, Jason; Y. Kim, Edy; Kuder, Julia; Mazza, Emílio; McLean, Dalton; Mosier, Jarrod; Moskowitz, Ari; A. Murphy, Sabina; L. O’Donoghue, Michelle; Park, Jeong‐Gun; Prasad, Rajnish; T. Ruff, Christian; N. Shahrour, Mohamad; S. Sinha, Shashank; D. Wiviott, Stephen; van Diepen, Sean; Zainea, Mark; M. Baird-Zars, Vivian; S. Sabatine, Marc; A. Morrow, David; Ah Im, Kyung; Saxena, Retu; M. Wiley, Brandon; Benson, Carina; Delamed, Roman; Skeik, Nedaa; Chopra, Ami; A. Judson, Marc; Beegle, Scott; Shkolnik, Boris; Tiwari, Anupama; F. Wu, Gregory; Raval, Abhijit; Branch, E.; Rischard, Franz; Hypes, Cameron; Bixby, Billie; Bime, Christian; Sundaram, Madhan; K. Sweitzer, Nancy; Vazquez Sandoval, Alfredo; D. White, Heath; M. Berg, Katherine; Shaefi, Shahzad; W. Donnino, Michael; Carroll, Brett; H. Ieong, Michael; Ackerbauer, Kimberly; Murphy, Jaime; S. Bhatt, Ankeet; Blood, Alexander; Patel, Siddharth; Luu, Victor; Narechania, Shraddha; Lorganger, Austin; Plambeck, Robert; Nayfeh, Ali; Sanley, Michael; Del Cor, Michel; J. Hegg, A.; Nara, Winston; Snyder, M; Khan, Faisal; Shawa, Imad; Larned, Joshua; Collado, Elias; Al Faiyumi, Mohammed; Mehta, Rajeev; Komanapalli, Sudarshan; Muppidi, Vijayadershan; J. Desai, Mehul; M. Flanagan, Casey; Genovese, Leonard; Haddad, Tariq; R. King, Christopher; Peterson, Amber; Htun, Thane; Pionk, Elizabeth; J. Mouawad, Nicolas; V. Nithish Kumar, C.; Nguyen, Kevin; Mughal, Majid; Malek, Ryan; Parekh, Akarsh; Provenzano, Christopher; Marie Ianitelli, Melissa; Prentice-Gaytan, Nicole; Bykowski, Adam; Tait, Don; Schendel, Shelley; Yalamanchili, Varun; Lala, Vasim; Hunyadi, Victor; Papolos, Alexander; B. Kenigsberg, Benjamin; Shenoy, Aarthi; Stuckey, Thomas; McQuaid, Douglas; Mannam, Praveen; McClung, Jeffrey; W. Nilsson, Kent; C. McKown, Andrew; B. Wells, Jason; Hotchkin, David; Jacobs, Marc; Strauss, Wayne; Balestra, Rick; Anik Sahni, V.; Jeffrey Snell, R.; Suradi, Hussam; Sungurlu, Sarah; Kuppy, J.; Gajo, Eileen; D. ADAMS, F.; Shehadeh, Abbas; Suleiman, Addi; Nandigam, Harish; Slim, Jihad; Ijlal Babar, Sardar; Baral, Dipti; Nawaz, Talha; Abdullah Waheed, Syed; Roth, Randy; Sitaula, Subhas; A Hayat, S; Babu, Jooby; Caberto, Jason; W. Hsu, Victor; W. Chang, Robert; R. Bochan, Markian; Garcia‐Cortes, Rafael; A. Skopicki, Hal; Chen, On; Pilato, Lauren; Richman, Paul; Adler, A.; Sudhindra, Praveen; Beversdorf, Jamie; Kashyap, Ravindra; Mehta, Parth; Mehrad, Borna; Ataya, Ali; Lascano, Jorge; Brantly, Mark; Austin, Adam; Koman, Eduard; Galski, Thomas; Vineeth Kumar, V; O. Soubani, Ayman; Harrison, N.; Reddy, Vineet; Fonkam, Audrey

doi:10.1161/circulationaha.122.061533

Public

Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT

Published in Circulation • Aug 29, 2022

Authors:

Erin A. Bohula

David D. Berg

Mathew S. Lopes

Abstract

Background: The efficacy and safety of prophylactic full-dose anticoagulation and antiplatelet therapy in critically ill COVID-19 patients remain uncertain. Methods: COVID-PACT (Prevention of Arteriovenous Thrombotic Events in Critically-ill COVID-19 Patients Trial) was a multicenter, 2×2 factorial,...

Subject

Medicine

Intensive care unit

Venous thrombosis

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