Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

Washizaki, Ayaka; Murayama, Asako; Murata, Megumi; Kiyohara, Tomoko; Yato, Keigo; Yamada, N.; Hassan Aly, Hussein; Tanaka, Tomohisa; Moriishi, Kohji; Nishitsuji, Hironori; Shimotohno, Kunitada; Goh, Yasumasa; J. Ishii, Ken; Yotsuyanagi, Hiroshi; Muramatsu, Masamichi; Ishii, Koji; Takahashi, Yoshimasa; Suzuki, Ryosuke; Akari, Hirofumi; Kato, Takanobu

doi:10.1038/s41467-022-32910-z

Public

Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

Published in Nature Communications • Sep 5, 2022

Authors:

Ayaka Washizaki

Asako Murayama

Megumi Murata

Abstract

Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of...

Subject

Virology

Neutralization

Hepatitis B virus

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