Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

E. Jansen, Iris; J. van der Lee, Sven; Gomez‐Fonseca, Duber; de Rojas, Itziar; Dalmasso, Carolina; Grenier‐Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Víctor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Ju Sung, Yun; Tesi, Niccoló; M. Vromen, Eleonora; P. Wightman, Douglas; Alcolea, Daniel; Alegret, Montserrat; Álvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Jan Biessels, Geert; Blennow, Kaj; Blesa, Rafael; Boada, Merçé; Boland, Anne; Büerger, Katharina; Carracedo, Ãngel; Cervera‐Carles, Laura; Chêne, Geneviève; A.H.R. Claassen, Jurgen; Debette, Stéphanie; Deleuze, Jean‐François; Paul De Deyn, Peter; Diehl‐Schmid, Janine; Djurovic, Srdjan; Dols‐Icardo, Oriol; Dufouil, Carole; Duron, Emmanuelle; Düzel, Emrah; Fladby, Tormod; Fortea, Juan; Frölich, Lutz; García‐González, Pablo; García‐Martínez, María; Giegling, Ina; Goldhardt, Oliver; Gobom, Johan; Grimmer, Timo; Haapasalo, Annakaisa; Hampel, Harald; Hanon, Olivier; Hausner, Lucrezia; Heilmann‐Heimbach, Stefanie; Helisalmi, Seppo; T. Heneka, Michael; Hernández, Isabel; Herukka, Sanna‐Kaisa; Holstege, Henne; Alexander Jarholm, Jonas; Kern, Silke; Knapskog, Anne‐Brita; M. Koivisto, Anne; Kornhuber, Johannes; Kuulasmaa, Teemu; Lage, Carmen; Laske, Christoph; Leinonen, Ville; Lewczuk, Piotr; Lleó, Alberto; López de Munain, Adolfo; López‐García, Sara; Maier, Wolfgang; Marquié, Marta; O. Mol, Merel; Montrreal, Laura; Moreno, Fermín; Moreno–Grau, Sonia; Nicolas, Gaël; M. Nöthen, Markus; Orellana, Adelina; Pålhaugen, Lene; M. Papma, Janne; Pasquier, Florence; Perneczky, Robert; Peters, Oliver; A.L. Pijnenburg, Yolande; Popp, Julius; Posthuma, Daniëlle; Pozueta, Ana; Priller, Josef; Puerta, Raquel; Quintela, Inés; Ramakers, Inez; Rodríguez‐Rodríguez, Eloy; Rujescu, Dan; Saltvedt, Ingvild; Sánchez‐Juan, Pascual; Scheltens, Philip; Scherbaum, Norbert; Schmid, Matthias; Schneider, Anja; Selbæk, Geir; Selnes, Per; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tárraga, Lluís; Teipel, Stefan; GR@ACE study group, The; M. Tijms, Betty; Tsolaki, Magda; Van Broeckhoven, Christine; Van Dongen, Jasper; C. van Swieten, John; Vandenberghe, Rik; Vidal, Jean‐Sébastien; Jelle Visser, Pieter; Vogelgsang, Jonathan; Wærn, Margda; Wagner, Michael; Wiltfang, Jens; Melissa Jane Wittens, Mandy; Zetterberg, Henrik; Zulaica, Miren; M. van Duijn, Cornelia; Bjerke, Maria; Engelborghs, Sebastiaan; Jessen, Frank; E. Teunissen, Charlotte; Pástor, Pau; Hiltunen, Mikko; Ingelsson, Martin; A. Andreassen, Ole; Clarimón, Jordi; Sleegers, Kristel; Ruiz, Agustı́n; Ramı́rez, Alfredo; Cruchaga, Carlos; Lambert, Jean‐Charles; M. van der Flier, Wiesje

doi:10.1007/s00401-022-02454-z

Public

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Published in Acta Neuropathologica • Sep 6, 2022

Authors:

Iris E. Jansen

Sven J. van der Lee

Duber Gomez‐Fonseca

Abstract

Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on gen...

Subject

Cerebrospinal fluid

Biobank

Pathogenesis

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