Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Termini, Rosalinda; Žihala, David; Terpos, Evangelos; Pérez-Montaña, Albert; Jelı́nek, Tomáš; S. Raab, Marc; Weinhold, Niels; Elias, K.; Luise Grab, Anna; Corre, Jill; Vergez, François; Sacco, Antonio; Chiarini, Marco; Giustini, Viviana; Tucci, Alessandra; Rodríguez, Sara; Moreno, Cristina; Pérez, Cristina; Maia, Catarina; Martín‐Sánchez, Esperanza; Guerrero, Camila; Botta, Cirino; Garcés, Juan‐José; López, Aitziber; Tamariz‐Amador, Luis‐Esteban; Prósper, Felipe; Bargay, Joan; Cabezudo, Maria-Elena; M. Ocio, Enrique; Hájek, Roman; Martínez‐López, Joaquín; Solano, Fernando; Iglesias, Rebeca; Paiva, Artur; Geraldes, Catarina; Vitória, Helena; Gómez, Clara; de Arriba, Felipe; Ludwig, Heinz; García‐Guiñón, Antoni; Casanova, María; Alegre, Adrían; Cabañas, Valentín; Sirvent, Maialen; Oriol, Albert; de la Rubia, Javier; Hernández‐Rivas, José‐Ángel; Palomera, Luis; Sarasa, Maria; Rios, Pablo; Puig, Noemí; Mateos, María‐Victoria; Flores‐Montero, Juan; Órfão, Alberto; Goldschmidt, Hartmut; Avet‐Loiseau, Hervé; M. Roccaro, Aldo; F. San Miguel, Jesús; Paiva, Bruno; behalf of the PETHEMA/GEM and iMMunocell Cooperative Groups, on

doi:10.1158/1078-0432.ccr-22-1594

Public

Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Published in Clinical Cancer Research • Sep 8, 2022

Authors:

Rosalinda Termini

David Žihala

Evangelos Terpos

Abstract

PURPOSE: Early intervention in smoldering multiple myeloma (SMM) requires optimal risk stratification to avoid under- and overtreatment. We hypothesized that replacing bone marrow (BM) plasma cells (PC) for circulating tumor cells (CTC), and adding immune biomarkers in peripheral blood (PB) for the ...

Subject

Immune system

Medicine

Risk stratification

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