Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice

Zhao, Tianming; Yu, Zihan; Zhou, Lei; Wang, Xiaoyu; Hui, Yangyang; Mao, Lihong; Fan, Xiaofei; Wang, Bangmao; Zhao, Xingliang; Sun, Chao

doi:10.1038/s41420-022-01173-4

Public

Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice

Published in Cell Death Discovery • Sep 7, 2022

Authors:

Tianming Zhao

Zihan Yu

Lei Zhou

Abstract

Abstract Hepatocellular death is a sensitive parameter for detecting acute liver injury (ALI) of toxic, viral, metabolic, and autoimmune origin. Ferroptosis has recently been implicated in carbon tetrachloride (CCl 4 )-induced ALI. However, the underpinning mechanism and mechanistic basis remain elu...

Subject

GPX4

Lipid peroxidation

Reactive oxygen species

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