Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals

Pinson, Anneline; Xing, Lei; Namba, Takashi; Kalebic, Nereo; Peters, Jula; Eugster Oegema, Christina; Traikov, Sofia; Reppe, Katrin; Riesenberg, Stephan; Maričić, Tomislav; P. Derihaci, Razvan; Wimberger, Pauline; Pääbo, Svante; Β. Huttner, Wieland

doi:10.1126/science.abl6422

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Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals

Published in Science • Sep 8, 2022

Authors:

Anneline Pinson

Lei Xing

Takashi Namba

Abstract

Neanderthal brains were similar in size to those of modern humans. We sought to investigate potential differences in neurogenesis during neocortex development. Modern human transketolase-like 1 (TKTL1) differs from Neanderthal TKTL1 by a lysine-to-arginine amino acid substitution. Using overexpressi...

Subject

Neocortex

Neurogenesis

Biology

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