Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Zhang, Qian; Pizzorno, Andrés; Miorin, Lisa; Bastard, Paul; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Manry, Jérémy; Rosain, Jérémie; Philippot, Quentin; Goavec, Kelian; Padey, Blandine; Čupić, Anastasija; Laurent, Emilie; Saker, Kahina; Vanker, Martti; Särekannu, Karita; Human Genetic Effort, COVID; Abel, Laurent; Aiuti, Alessandro; Al‐Muhsen, Saleh; Al‐Mulla, Fahd; S. Anderson, Mark; Andreakos, Evangelos; A. Arias, Andrés; Baris Feldman, Hagit; Belot, Alexandre; M. Biggs, Catherine; Bogunovic, Dusan; Bolze, Alexandre; Bondarenko, Anastasiia; Aziz Bousfiha, Ahmed; Brodin, Petter; T. Bryceson, Yenan; D. Bustamante, Carlos; J. Butte, Manish; Casari, Giorgio; Christodoulou, John; Condino-Neto, Antonio; N. Constantinescu, Stefan; A. Cooper, Megan; L. Dalgard, Clifton; Desai, Murkesh; A. Drolet, Beth; El Baghdadi, Jamila; Elva Espinosa‐Padilla, Sara; Fellay, Jacques; Flores, Carlos; C. Fragkou, Paraskevi; Luis Barrera Franco, José; Froidure, Antoine; E. Galani, Ioanna; K. Gregersen, Peter; Grimbacher, Bodo; Haerynck, Filomeen; Hagin, David; Halwani, Rabih; Hammarström, Lennart; R. Heath, James; E. Henrickson, Sarah; W.Y. Hsieh, Elena; Husebye, Eystein; Imai, Kohsuke; Itan, Yuval; D. Jarvis, Erich; Karamitros, Timokratis; Kisand, Kai; Koltsida, Ourania; Ku, Cheng‐Lung; Lau, Yu-Lung; Ling, Yun; Lucas, C.; Maniatis, Tom; Mansouri, Davood; Maródi, László; Meyts, Isabelle; D. Milner, Joshua; Mironska, Kristina; H. Mogensen, Trine; Morio, Tomohiro; F. P. Ng, Lisa; D. Notarangelo, Luigi; Novelli, Antonio; Novelli, Giuseppe; O’Farrelly, Cliona; Okada, Satoshi; Okamoto, Keisuke; Özçelık, Tayfun; Pan‐Hammarström, Qiang; W. Pape, Jean; Pérez de Diego, Rebeca; S. Perlin, David; Pesole, Graziano; M. Planas, Anna; Prando, Carolina; Pujol, Aurora; Quintana-Murci, Lluis; Ramaswamy, Sathishkumar; Rapti, Vasiliki; Rénia, Laurent; Resnick, Igor; Rodríguez-Gallego, Carlos; Ρovina, Νikoletta; Sancho‐Shimizu, Vanessa; Šedivá, Anna; Seppänen, Mikko; Shahrooei, Mohammed; Shcherbina, Anna; Slabý, Ondřej; L. Snow, Andrew; Soler‐Palacín, Pere; N. Spaan, András; Tancevski, Ivan; G. Tangye, Stuart; Abou Tayoun, Ahmad; Gülsün Temel, Şehime; Tsiodras, Sotirios; E. Turvey, Stuart; M. Furkan Uddin, K.; Uddin, Mohammed; van de Beek, Diederik; C. Vinh, Donald; von Bernuth, Horst; Wauters, Joost; Zatz, Mayana; Zawadzki, Paweł; C. Su, Helen; Casanova, Jean‐Laurent; Français du Sang Study Group, Etablissement; Morel, Pascal; Richard, Pascale; Bonneaudeau, Brigitte; Cannet, Dorothée; Gallian, Pierre; Jeanne, Michel; Perroquin, Magali; Hamzeh‐Cognasse, Hind; Cognasse, Fabrice; Tiberghien, Pierre; Cohort, Constances; Nadif, Rachel; Goldberg, Marcel; Ozguler, Anna; Henny, Joseph; Lemonnier, Sylvie; Coeuret-Pellicer, Mireille; Le Got, Stéphane; Zins, Marie; Study, 3C-Dijon; Tzourio, Christophe; Debette, Stéphanie; Dufouil, Carole; Soumaré, Aïcha; Lachaize, Morgane; Fievet, Nathalie; Flaig, Amandine; HealthCare Group, Cerba; Martin, Fernando; Mehlal-Sedkaoui, Souad; Sallette, Jérôme; Antigrippe Working Group, Lyon; Hernu, Romain; Lina, Bruno; Schwebel, Carole; Wroblewski, I.; Morand, Patrice; Souweine, Bertrand; Boeuf, Benoit; Peigue‐Lafeuille, H.; Darmon, Michaël; Patural, Hugues; Pozzetto, Bruno; Quenot, Jean‐Pierre; Colomb, Benoit; Pothier, Pierre; Bélot, Alexandre; INF Working Group, REIPI; Abad Arranz, María; Aguilar Guisado, Manuela; Escoresca Ortega, Ana; Ríos, Rafaela; Merino Díaz, Laura; Del Mar Muñoz Garcia, Maria; Ramírez Duque, Nieves; María Romero Vázquez, Gloria; Jose Sánchez Cordero, Maria; Salamanca Rivera, Celia; Niubó, Jordí; Rombauts, Alexander; Navarrete, Nicolás; Romero Oraa, Laura; Palomo, Virginia; García‐Salum, Tamara; Ferrés, Marcela; Le Corre, Nicole; Sánchez‐Céspedes, Javier; Balsera-Manzanero, María; Carratalà, Jordi; Retamar, Pilar; Abelenda-Alonso, Gabriela; Valiente, Adoración; Tiberghien, Pierre; Zins, Marie; Debette, Stéphanie; Meyts, Isabelle; Haerynck, Filomeen; Castagnoli, Riccardo; D. Notarangelo, Luigi; Ignacio González‐Granado, Luis; Domínguez‐Pinilla, Nerea; Andreakos, Evangelos; Triantafyllia, Vasiliki; Rodríguez-Gallego, Carlos; Solé‐Violán, Jordi; Ruiz-Hernández, J.J.; Rodrı́guez de Castro, Felipe; Ferreres, José; Luisa Briones, M.; Wauters, Joost; Vanderbeke, Lore; Feys, Simon; Kuo, Chen-Yen; Lei, Wei‐Te; Ku, Cheng‐Lung; Tal, Galit; Etzioni, A; Hanna, Suhair; Fournet, Thomas; Casalegno, Jean‐Sébastien; Quéromès, Grégory; Argaud, Laurent; Javouhey, Étienne; Rosa‐Calatrava, Manuel; Cordero, Elisa; Aydillo, Teresa; Medina, Rafael; Kisand, Kai; Puel, Anne; Jouanguy, Emmanuelle; Abel, Laurent; Cobat, Aurélie; Trouillet‐Assant, Sophie; García‐Sastre, Adolfo; Casanova, Jean‐Laurent

doi:10.1084/jem.20220514

Public

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Published in The Journal of Experimental Medicine • Aug 9, 2022

Authors:

Qian Zhang

Andrés Pizzorno

Lisa Miorin

Abstract

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6...

Subject

Autoantibody

Medicine

Immunology

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