Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease

Kamagata, Koji; Andica, Christina; Takabayashi, Kaito; Saito, Yuya; Taoka, Toshiaki; Nozaki, Hayato; Kikuta, Junko; Fujita, Shohei; Hagiwara, Akifumi; Kamiya, Kouhei; Wada, Akihiko; Akashi, Toshiaki; Sano, Katsuhiro; Nishizawa, Mitsuo; Hori, Masaaki; Naganawa, Shinji; Aoki, Shigeki; the Alzheimer's Disease Neuroimaging Initiative, for

doi:10.1212/wnl.0000000000201300

Public

Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease

Published in Neurology • Sep 19, 2022

Authors:

Koji Kamagata

Christina Andica

Kaito Takabayashi

Abstract

Background and Objectives The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal role in amyloid β (Aβ) accumulation. However, its involvement in Alzheimer disease (AD) pathogenesis is not fully under...

Subject

Glymphatic system

Cognition

Association (psychology)

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