Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer

Cheng, Ying; Han, Liang; Wu, Lin; Chen, Jun; Sun, Hongmei; Wen, Guilan; Ji, Yinghua; Dvorkin, Mikhail; Shi, Jianhua; Pan, Zhijie; Shi, Jinsheng; Wang, Xicheng; Bai, Yuansong; Melkadze, Tamar; Pan, Yueyin; Min, Xuhong; Viguro, Maksym; Li, Xingya; Zhao, Yanqiu; Yang, Junquan; Makharadze, Tamta; Arkania, Ekaterine; Kang, Wenying; Wang, Qingyu; Zhu, Jun; Study Group, ASTRUM-005; Ren, Xiubao; Kuchava, Vladimer; Sun, Guoping; Li, Gaofeng; Wen, Lin; Zhang, Tao; Harputluoğlu, Hakan; Çiçin, İrfan; Feng, Guosheng; Hao, Yanrong; Ying, Kejing; Sun, Ping; Zhong, Aihong; An, Guangyu; Wang, Yan; Chen, Chun; Yang, Sheng; Chen, Zhendong; Penkov, Konstantin; Semegen, Yuriy; Kobziev, Oleg; Luo, Feng; Cao, Peiguo; Yang, Zhixiong; Fan, Min; Li, Wen; Mróz, Robert; Л. Акопов, А.; Göksel, Tuncay; Gümüş, Mahmut; Zhuo, Wenlei; Fang, Jian; Zhao, Hui; Zhong, Lin; Hu, Yanping; Li, Yarong; Zhang, Shuqun; Cui, Jiuwei; В. Коваленко, Н.; Arslan, Çağatay; Cabuk, Devrim; Türker, Alev; Bondarenko, Igor; Hotko, Yevhen; Goloborodko, O.; Chen, Dongji; Wang, Mengzhao; Yu, Zhuang; Lu, Jun‐Guo; Jiang, Liyan; Xiong, Hao; Giorgadze, Davit; Orlov, Sergey; Bılıcı, Ahmet; Sinelnikov, Ivan; Chen, Gongyan; Lu, Yue; Zhu, Xiaoli; Lu, Liqin; Zhvania, Mariam; Ułańska, Małgorzata; Lifirenko, Igor; Andabekov, Timur; Smagina, Maria; Moiseenko, Fedor; Ürün, Yüksel; Nie, Ligong; Cao, Bangwei; You, Zhenyu; Huang, Haixin; Ying, Shenpeng; Tavartkiladze, Alexandre; Kitiashvili, Tariel; Matitashvili, Amiran; Kortua, Tsira; P. Kulikov, Eugeny; Cheporov, Sergey; Shirinkin, Vadim; Özgüroğlu, Mustafa; Artaç, Mehmet; Kolesnik, Oleksii; Gardashnikov, Andrii; Pominchuk, Denys

doi:10.1001/jama.2022.16464

Public

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer

Published in JAMA • Sep 27, 2022

Authors:

Ying Cheng

Liang Han

Lin Wu

Abstract

Importance: Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients with extensive-stage small cell lung cancer (SCLC). It remained unknown whether adding a programmed cell death 1 (PD-1) inhibitor to chemotherapy provided sim...

Subject

Medicine

Internal medicine

Carboplatin

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