PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

Codarri Deak, Laura; Nicolini, Valeria; Hashimoto, Masao; Karagianni, Maria; Schwalie, Petra; Lauener, Laura; Maria Varypataki, Eleni; Richard, Marine; Bommer, Esther; Sam, Johannes; Joller, Stefanie; Perro, Mario; Cremasco, Floriana; Kunz, Leo; Yángüez, Emilio; Hüsser, Tamara; Schlenker, Ramona; Mariani, Marisa; Toševski, Vinko; Herter, Sylvia; Bacac, Marina; Waldhauer, Inja; Colombetti, Sara; Guéripel, Xavier; Wullschleger, Stephan; Tichet, Mélanie; Hanahan, Douglas; Kissick, Haydn; Leclair, Stéphane; Freimoser–Grundschober, Anne; Seeber, Stefan; Teichgräber, Volker; Ahmed, Rafi; Klein, Christian; Umaña, Pablo

doi:10.1038/s41586-022-05192-0

Public

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

Published in Nature • Sep 28, 2022

Authors:

Laura Codarri Deak

Valeria Nicolini

Masao Hashimoto

Abstract

Abstract Expansion and differentiation of antigen-experienced PD-1 + TCF-1 + stem-like CD8 + T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade 1–4 . Hashimoto et al. have shown that, in chronic infections, administration of the cytokine interleukin (IL...

Subject

IL-2 receptor

Cytotoxic T cell

CD8

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