CAR T cells targeting
                    <i>Aspergillus fumigatus</i>
                    are effective at treating invasive pulmonary aspergillosis in preclinical models

Seif, Michelle; Katharina Kakoschke, Tamara; Ebel, Frank; Maria Bellet, Marina; Trinks, Nora; Renga, Giorgia; Pariano, Marilena; Romani, Luigina; Tappe, Beeke; Espie, David; Donnadieu, Emmanuel; Hünniger, Kerstin; Häder, Antje; Sauer, Markus; Damotte, Diane; Alifano, Marco; Lewis White, P.; Backx, Matthijs; Nerreter, Thomas; Machwirth, Markus; Kurzai, Oliver; Prommersberger, Sabrina; Einsele, Hermann; Hudecek, Michael; Löffler, Jürgen

doi:10.1126/scitranslmed.abh1209

Public

CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models

Shared by NobleBlocks on Sep 28, 2022 • 12:00 AM UTC

Authors:

Michelle Seif

Tamara Katharina Kakoschke

Frank Ebel

Abstract

Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis (IPA). Adaptive and innate immune cells that respond to A. fumigatus are present in the endogenous repertoire of patients with IPA but ...

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