Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Møller, Pål; T. Seppälä, Toni; G. Dowty, James; Haupt, Saskia; Dominguez–Valentin, Mev; Sunde, Lone; Bernstein, Inge; Engel, Christoph; Aretz, Stefan; Nielsen, Maartje; Capellá, Gabriel; Gareth Evans, D.; Burn, John; Holinski‐Feder, Elke; Bertario, Lucio; Bonanni, Bernardo; Lindblom, Annika; Levi, Zohar; Macrae, Finlay; Winship, Ingrid; Plazzer, John‐Paul; H. Sijmons, Rolf; Laghi, Luigi; Della Valle, Adriana; Heinimann, Karl; Half, Elizabeth; Lopez-Koestner, Francisco; Alvarez-Valenzuela, Karin; J. Scott, Rodney; H. Katz, Lior; Laish, Ido; Vainer, E; Vaccaro, Carlos; Maria Carraro, Dirce; Gluck, Nathan; Abu‐Freha, Naim; Stakelum, Áine; Kennelly, Rory; C. Winter, D.; Rossi, Bernard; S. Greenblatt, Marc; Bohórquez, Mábel; Sheth, Harsh; Grazia Tibiletti, Maria; S. Lino‐Silva, Leonardo; Horisberger, Karoline; Portenkirchner, Carmen; do Nascimento, Ivana; Rossi, Norma; Apolinário da Silva, Leandro; Thomas, Huw; Zaránd, Attila; Mecklin, Jukka‐Pekka; Pylvänäinen, Kirsi; Renkonen‐Sinisalo, Laura; Lepistö, Anna; Peltomäki, Païvi; Therkildsen, Christina; Joachim Lindberg, Lars; Thorlacius‐Ussing, Ole; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Steinke‐Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Hüneburg, Robert; Falcón de Vargas, Aı́da; Latchford, Andrew; Gerdes, Anne‐Marie; Bäckman, A; Guillén‐Ponce, Carmen; Snyder, Carrie; Kvist Lautrup, Charlotte; J. Amor, David; Inêz Palmero, Edenir; M. Stoffel, Elena; A.M. Duijkers, Floor; J. Hall, Michael; Hampel, Heather; Williams, Heinric; Okkels, Henrik; Lubiński, Jan; C. Reece, Jeanette; Ngeow, Joanne; G. Guillem, José; Arnold, Julie; Wadt, Karin; Monahan, Kevin; Senter, Leigha; Juel Rasmussen, Lene; P. van Hest, Liselotte; Ricciardiello, Luigi; R.J. Kohonen‐Corish, Maija; J. L. Ligtenberg, Marjolijn; C. Southey, Melissa; Aronson, Melyssa; Nizam Zahary, Mohd; Jewel Samadder, N.; Poplawski, Nicola; Hoogerbrugge, Nicoline; J. Morrison, Patrick; A. James, Paul; Lee, Grant; Chen‐Shtoyerman, Rakefet; Ankathil, Ravindran; K. Pai, Rish; L. Ward, Robyn; Parry, Susan; Dębniak, Tadeusz; John, Thomas; van Overeem Hansen, Thomas; Caldés, Trinidad; Yamaguchi, Tatsuro; Barca-Tierno, Verónica; Garré, Pilar; Martina Cavestro, Giulia; Weitz, Jürgen; Redler, Silke; Büttner, Reinhard; Heuveline, Vincent; L. Hopper, John; Ko Win, Aung; M. Lindor, Noralane; Gallinger, Steven; Le Marchand, Loı̈c; A. Newcomb, Polly; C. Figueiredo, Jane; D. Buchanan, Daniel; N. Thibodeau, Stephen; W. ten Broeke, Sanne; Hovig, Eivind; Nakken, Sigve; Pineda, Marta; Dueñas, Núria; Brunet, Joan; Green, Kate; Lalloo, Fiona; Newton, Katie; J. Crosbie, Emma; Mints, Miriam; Tjandra, Douglas; Neffa, Florencia; Esperón, Patricia; Kariv, Revital; Rosner, Guy; Pavicic, Walter; Kalfayan, Pablo; Tardin Torrezan, Giovana; Bassaneze, Thiago; Martin, Claudia; Möslein, Gabriela; Ahadova, Aysel; Kloor, Matthias; R. Sampson, Julian; A. Jenkins, Mark

doi:10.1186/s13053-022-00241-1

Public

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Published in Hereditary Cancer in Clinical Practice • Oct 1, 2022

Authors:

Pål Møller

Toni T. Seppälä

James G. Dowty

Abstract

OBJECTIVE: To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. METHODS: CRC incidences were calculated in an intervention group compr...

Subject

Lynch syndrome

Medicine

DNA mismatch repair

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