The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment

Yamamoto, Yurie; Kasashima, Hiroaki; Fukui, Yasuhiro; Tsujio, Gen; Yashiro, Masakazu; Maeda, Kiyoshi

doi:10.1111/cas.15609

Public

The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment

Published in Cancer Science • Oct 5, 2022

Authors:

Yurie Yamamoto

Hiroaki Kasashima

Yasuhiro Fukui

Abstract

The prognosis for patients with cancers known for a highly activated stromal reaction, including diffuse-type (scirrhous) gastric cancer, consensus molecular subtype 4 (CMS4) colorectal cancer, and pancreatic ductal adenocarcinoma, is extremely poor. To explore the resistance of conventional therapy...

Subject

Tumor microenvironment

Cancer-Associated Fibroblasts

Stromal cell

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