Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

E. Geyer, Charles; E. Garber, Judy; D. Gelber, Richard; Yothers, Greg; Taboada, Manuel; Ross, L.; Rastogi, Priya; Cui, Karen; Arahmani, Amal; Aktan, Gursel; Armstrong, Anne; Arnedos, Mónica; Balmaña, Judith; Bergh, Jonas; M. Bliss, Judith; Delaloge, Suzette; M. Domchek, Susan; Eisen, Andrea; Elsafy, F.; Fein, L.E.; Fielding, Anitra; M. Ford, James; Friedman, Sue; A. Gelmon, Karen; Gianni, Luca; Gnant, Michael; J. Hollingsworth, Simon; Im, Seock‐Ah; Jager, Agnes; T. Johannsson, Oskar; R. Lakhani, Sunil; Janni, W; Linderholm, Barbro; Liu, T.-W.; Loman, Niklas; A. Korde, Larissa; Loibl, Sibylle; C. Lucas, Peter; Marmé, Frederik; Martinez de Dueñas, E.; McConnell, Robin; Phillips, Kelly‐Anne; Piccart, Martine; Rossi, Giovanna; K. Schmutzler, Rita; Senkus, Elżbieta; Shao, Zhi-Ming; Sharma, Priyanka; F. Singer, Christian; Španić, Tanja; Stickeler, Elmar; Toi, Masakazu; A. Traina, Tiffany; Viale, Giuseppe; Zoppoli, Gabriele; Park, Y.H.; Yerushalmi, Rinat; Yang, Huan; Pang, D.; Hae Jung, Kyung; Mailliez, Audrey; Fan, Zhaoqing; Tennevet, Isabelle; Zhang, J.; Nagy, T.; S. Sonke, Gabe; Sun, Qiuhong; Parton, Marina; Colleoni, Marco; Schmidt, Marcus; Brufsky, Adam; Razaq, W.; Kaufman, Bella; Cameron, David; Campbell, Christine; Tutt, Andrew; Sevelda, P.; Haslbauer, Ferdinand; Penzinger, Monika; Öhler, Leopold; Tinchon, Christoph; Greil, Richard; Heibl, Sonja; Bartsch, Rupert; Wette, Viktor; F. Singer, Christian; Pasterk, Claudia; Helfgott, Ruth; Pristauz-Telsnigg, Gunda; Stöger, Herbert; Weltermann, A.; Egle, Daniel; Thiel, I.; Fuchs, David; Rumpold, Holger; Strasser‐Weippl, Kathrin; Rautenberg, Beate; Müller, Volkmar; Schmidt, Marcus; Paepke, Stefan; Aydoğdu, Mustafa; Thomssen, Christoph; Rom, Joachim; Mau, Christine; A. Fasching, Peter; Göhring, Uwe-Jochen; Kühn, Thorsten; Noeding, S; Kümmel, Sherko; Hackmann, John; Stickeler, Elmar; Joshi, Abhishek; Dewar, Joanna; Friedländer, Michael; Phillips, Kelly‐Anne; Antill, Yoland; Woodward, Natasha; Abdi, Ehtesham; Tiley, Susan; George, Mathew; Boadle, David; Goodwin, Annabel; van der Westhuizen, André; Kannourakis, George; Murray, N.; McCarthy, Nicole; R. Kroep, Judith; de Boer, Maaike; B. Heijns, Joan; Jager, Agnes; Erdkamp, Franciscus; D. Bakker, Sandra; S. Sonke, Gabe; Sami, Amer; M. Mackey, John; Prady, Catherine; Eisen, Andrea; Desbiens, Christine; Patocskai, Érica; Ferrario, Cristiano; A. Gelmon, Karen; Bordeleau, Louise; Chalchal, Haji; Niraula, Saroj; Wolf, Ido; Senkus, Elżbieta; Duhoux, François; D’hondt, Randal; Luce, Sylvie; t’Kint de Roodenbeke, Daphné; Papadimitriou, Konstantinos; Borms, Marleen; Quaghebeur, Claire; Jacot, William; Brain, Etienne; Venat‐Bouvet, Laurence; Lortholary, Alain; Nowecki, Zbigniew; Cardoso, Fátima; Hayward, Richard; Bella, Santiago; Fernández Lazzaro, Mauricio; Pilnik, N.; Fein, Luis; Blajman, C.; Lerzo, Guillermo; Varela, Mirta; José Zarbá, Juan; Kaen, Diego; Victoria Constanzo, Maria; Tio, Joke; Siggelkow, Wulf; Jackisch, Christian; Maria Grischke, Eva; Zahm, D.-M.; Tato-Varela, Sara; Schmatloch, Sabine; Klare, Peter; Stefek, Andrea; Rhiem, Kerstin; Hoffmann, Oliver; Kümmel, Sherko; Deryal, Mustafa; Gröll, Isolde; Ledwon, P.; Uleer, Christoph; Krabisch, Petra; Potenberg, Jochem; Darsow, Maren; Park‐Simon, Tjoung‐Won; Höffkes, Heinz‐Gert; Emde, Till‐Oliver; Graffunder, Gerd; Tomé, Oliver; Forstmeyer, Dirk; Terhaag, Jürgen; Salat, Christoph; Kast, Karin; Weniger, Steffi; Schreiber, Carsten; Heinrich, Bernhard; Dieterich, Max; Penelope Wüllner, Michaela; Andrés Conejero, Raquel; Á. García-Sáenz, José; Calvo Martinez, Lourdes; Arcusa Lanza, Angels; Morales Murillo, Serafín; Henao, Fernando; Blanch Tormo, Salvador; Álvarez López, Isabel; Ignacio Delgado Mingorance, Juan; Álvarez Gomez, Elena; Santisteban, Marta; Cruz Jurado, Josefina; Quiroga, Vanesa; Ruiz Borrego, Manuel; Martínez de Dueñas, Eduardo; Enrique Alés Martínez, Jose; de la Haba-Rodríguez, Juan; Martínez-Jáñez, Noelia; Rodríguez Lescure, Álvaro; Antón Torres, Antonio; Llort Crusades, Gema; González-Santiago, Santiago; Marquez Aragones, Antonia; Laura Ortega Granados, Ana; Barnadas Molins, A.; Ignacio Chacón, José; Martín Jiménez, M.; Santaballa Bertrán, Ana; Rodríguez Rodríguez, C.; González Cortijo, Lucía; Cretella, Elisabetta; Cortesi, Laura; Maria Ruggeri, Enzo; Verusio, Claudio; Gori, Stefania; Bonetti, Andrea; Maria Mosconi, Anna; T. Johannsson, Oskar; Jérusalem, Guy; Neven, Patrick; Nagy, Tünde; Pinotti, Graziella; Colleoni, Marco; Bernardo, Antônio; Gianni, Lorenzo; Bucci, Eugênio; Biganzoli, Laura; J. Dedes, Konstantin; Novak, Urban; Zaman, Khalil; Braybrooke, Jeremy; Winter, Matthew; Rea, Daniel; Kelleher, Muireann; Barrett, Sophie; L. Chan, Stephen; Hickish, Tamas; Hurwitz, Jane; Conibear, John; Jegannathen, A.; Parton, Marina; Tutt, Andrew; Allerton, R.; Borley, Annabel; Armstrong, Anne; Copson, Ellen; C Levitt, N; Abraham, Jean; Perren, Timothy; Roylance, Rebecca; Ishida, Kazushige; Toyama, Tatsuya; Masuda, Norikazu; Watanabe, Junichiro; Tokunaga, Eriko; Kinoshita, Takayuki; Rai, Yoshiaki; Takada, Masahiro; Yanagita, Yasuhiro; Nakamura, Rikiya; Nakayama, Takahiro; Naoi, Yasuto; Iwata, Hiroji; Nakamura, Seigo; Takahashi, Masato; Aogi, Kenjiro; Tsugawa, Koichiro; Mukai, Hirofumi; Takano, Toshimi; Osaki, Akihiko; Sato, Nobuaki; Yamauchi, Hideko; Tokuda, Yutaka; Ito, Mitsuya; Sugimoto, Takeki; Bahadur, Shakeela; A. Ganz, Patricia; J. Lu, Min; J. Lu, Min; Mita, Monica; Waisman, James; A. Polikoff, Jonathan; L. Telli, Melinda; A. Seaward, Samantha; M. Suga, Jennifer; A. Seaward, Samantha; Marie Suga, J.; N. Durna, Lara; Fu Carney, Jennifer; R. Menter, Alex; Marie Suga, J.; Puthillath, Ajithkumar; A. Polikoff, Jonathan; M. Suga, Jennifer; Rohatgi, Nitin; M. Suga, Jennifer; A. Polikoff, Jonathan; A. Polikoff, Jonathan; H. Feusner, James; Bobolis, Kristie; A. Polikoff, Jonathan; D. Eisenberg, Peter; Marie Suga, J.; A. Polikoff, Jonathan; Wong, Derrick; F. Borges, Virginia; T. Urquhart, Alexander; Hofstatter, Erin; W. Hofstatter, Erin; W. Hofstatter, Erin; C. McCarron, Edward; Isaacs, Claudine; Herbolsheimer, Pia; Varadarajan, Ramya; Raben, Adam; Anne E. Deveras, Ruby; Valdes-Albini, Frances; L. Mahtani, Reshma; L. Mahtani, Reshma; Meisel, Jane; T. Sumrall, Bradley; Jones, Cheryl; Ofori, Samuel; N.M. Sumida, Kenneth; N.M. Sumida, Kenneth; Karwal, Mark; W. Wilbur, Deborah; , Singh; Spector, David; M. Schallenkamp, John; E. Merkel, Douglas; S. Lo, Shelly; Khosla, Pam; Cristofanilli, Massimo; Flaum, Lisa; Hoskins, Kent; Cobleigh, Melody; A. Lambiase, Elyse; Hahn, Olwen; A. Oliff, Ira; A. Faller, Bryan; L. Wade, James; Burhani, Nafisa; L. Wade, James; Gil, Amaryllis; Einhorn, Harvey; Storniolo, A.M.; K. Chang, Brian; Kalra, Maitri; Robin, Erwin; Ansari, Bilal; Sharma, Priyanka; R. Dakhil, Shaker; R. Dakhil, Shaker; L. Deming, Richard; T. Cole, John; T. Cole, John; T. Cole, John; S. Hanson, David; C. Ochoa, Augusto; T. Cole, John; C. Ochoa, Augusto; E. Garber, Judy; E. Garber, Judy; Zimbler, Harvey; K. Armstrong, Deborah; H. R. Tkaczuk, Katherine; Riseberg, David; K. Armstrong, Deborah; O’Connor, Brian; H. Openshaw, Thomas; H. Openshaw, Thomas; H. Openshaw, Thomas; Zakalik, Dana; Vakhariya, Cynthia; F. Schott, Anne; S. Simon, Michael; J. Doyle, Thomas; Al Baghdadi, Tareq; VanderWoude, Amy; J. Flynn, Patrick; T. Zera, Richard; Edward Buckley Friday, Bret; J. Ruddy, Kathryn; T. Zera, Richard; Smith, Ron; J. Flynn, Patrick; , Ademuyiwa; Olabisi, Foluso; Ellis, Robert; W. Carlson, Jay; W. Carlson, Jay; , Marchello; Benjamin, Tania; A. Levine, Edward; Kelly Marcom, P.; Harkness, C.; R. Tan, Antoinette; Charles, W.; Kuzma, Charles; Asaad, Shonda; E. Radford, James; D. Steen, Preston; Unnikrishnan, Madhu; R. Seeger, Grant; M.H. Leu, Kirsten; S Copur, Mehmet; J. Hauke, Ralph; S. Soori, Gamini; J. Hauke, Ralph; A. Arrick, Bradley; G. Reeder, Jennifer; Toppmeyer, Deborah; Dayao, Zoneddy; Adams, Sylvia; Andreopoulou, Eleni; Allison, Magnuson; D. Anampa Mesias, Jesus; Sharma, Ruby; Ramaswamy, Bhuvaneswari; T. Gerds, Aaron; R. Shenk, Robert; M. Gross, Howard; Trehan, Shruti; M. Gross, Howard; M. Gross, Howard; M. Gross, Howard; R. Shenk, Robert; M. Gross, Howard; R. Shenk, Robert; Razaq, Wajeeha; Mansoor, Abdul; Hilton, Christie; Brufsky, Adam; Huynh, Chanh; Chowdhury, Nabila; M. Domchek, Susan; R. Sigurdson, Elin; P. Cescon, Terrence; A. Rovito, Marc; S. DeNittis, Albert; G. Vogel, Victor; B. Julian, Thomas; Boyle, Lucy; Báez-Díaz, Luis; BRESCIA, FRANK; E. Doster, John; D. Siegel, Robert; Wong, Lucas; Patel, Tejal; R. Nangia, Julie; A. Jones, Catherine; M. Cannon, George; M. Cannon, George; D. Bear, Harry; Vachhani, Hetal; Wilkinson, Mary; E. Wood, Marie; E. Wood, Marie; Yan, Fengting; Sui, Xingwei; M. van Haelst, Carol; M. Specht, Jennifer; Zhuo, Ying; Qamar, Rubina; L. Ryan, Matthew; L. Stockham, Abigail; Virani, Shamsuddin; Qamar, Rubina; A. Gayle, Arlene; Qamar, Rubina; Qamar, Rubina; J. Jubelirer, Steven; Kurian, Sobha; A. Salkeni, Mohamad; Loman, Niklas; Linderholm, Barbro; Silander, Gustav; Hallbeck, Anna‐Lotta; von Wachenfeldt Väppling, Anna; Curtit, Elsa; Cardoso, Catarina; Braga, Sofía; Abreu, Miguel; Casa-Nova, Mafalda; Nave, Mónica; María Ciruelos Gil, Eva; Balmaña Gelpí, Judith; Fernandez Ortega, A.; Gumà Padró, Josep; Bermejo De Las Heras, B.; González Cao, María; Cueva Bañuelos, Juan; Viñas Villaró, Gemma; Estevez, L; Huober, Jens; Busch, Steffi; Fehm, Tanja; Hahn, Antje; Gräfe, Andrea; Noesselt, Thomas; Dewitz, Thomas; Wagner, Harald; Bechtner, Christina; Weigel, Michael; Kolberg, Hans‐Christian; Decker, Thomas; Thomalla, Jörg; Hesse, Tobias; Harbeck, Nadia; Schröder Jens-Uwe Blohmer, Jan; Sütterlin, Marc; Altena, Renske; Chiu, Chang-Fang; Chen, Shin‐Cheh; Hou, Ming‐Feng; Chang, Yuan‐Ching; Chen, Shang‐Hung; Chen, Shou-Tung; Huang, Chiun‐Sheng; Yeh, Dah‐Cherng; Yu, Jyh-Cherng; Tseng, Ling‐Ming; Chung, Wei‐Pang; Mailliez, Audrey; Petit, Thierry; Delaloge, Suzette; Lévy, Christelle; Dalivoust, P.; Extra, Jean-Marc; Mouret‐Reynier, Marie‐Ange; Hardy‐Bessard, Anne‐Claire; Simon, H.; L'Haridon, Tiffenn; Mège, Alice; Giacchetti, Sylvie; Chakiba-Brugère, Camille; Gratet, Alain; Pottier, V.; Ferrero, Jean-­Marc; Tennevet, Isabelle; Perrin, Christophe; Canon, Jean-Luc; Joris, Sofie; Shao, Zhimin; Xu, Binghe; Jiang, ZeFei; Sun, Qiang; Shen, Kunwei; Pang, Da; Zhang, Jin; Wang, Shui; Yang, Hongjian; Liao, Ning; Zheng, Hong; Fu, Peifen; Song, Chuangui; Wang, Yongsheng; Fan, Zhimin; Geng, Cuizhi; Trédan, Olivier; Landherr, László; Kaufman, Bella; Yerushalmi, Rinat; Uziely, Beatrice; Conte, PierFranco; Zamagni, Claudio; Bianchini, Giampaolo; De Laurentiis, Michelino; Tondini, Carlo; Gebbia, Vittorio; Ciccarese, Mariangela; Sarosiek, Tomasz; Mackiewicz, Jacek; Słowińska, Anna; Kalinka‐Warzocha, Ewa; Huzarski, Tomasz; Im, Seock‐Ah; Hae Jung, Kyung; Sohn, Joohyuk; Hyun Kim, Jee; Seok Lee, Keun; Hee Park, Yeon; Eun Lee, Kyoung; Soo Chae, Yee; Kyung Cho, Eun

doi:10.1016/j.annonc.2022.09.159

Public

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

Published in Annals of Oncology • Oct 10, 2022

Authors:

Charles E. Geyer

Judy E. Garber

Richard D. Gelber

Abstract

BACKGROUND: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-ri...

Subject

Medicine

Olaparib

Internal medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!