Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis

Qiu, Shengkui; Xie, Li; Chen, Lu; Gu, Chao; Xia, Yiwen; Lv, Jialun; Xuan, Zhe; Fang, Lang; Yang, Jing; Zhang, Lu; Li, Zheng; Wang, Weizhi; Xu, Hao; Li, Bowen; Xu, Zekuan

doi:10.1186/s13046-022-02499-8

Public

Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis

Published in Journal of Experimental & Clinical Cancer Research • Oct 10, 2022

Authors:

Shengkui Qiu

Li Xie

Lu Chen

Abstract

BACKGROUND: Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC-LM) remains unknown. Exosomes have been identified as an important mediator of communication between tumor cells and the ...

Subject

Microvesicles

Exosome

microRNA

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