PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Wang, Lu; Li, Shuangshuang; Luo, Huanhua; Long Lu, Qi; Yu, Shuwen

doi:10.1186/s13046-022-02477-0

Public

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Published in Journal of Experimental & Clinical Cancer Research • Oct 14, 2022

Authors:

Lu Wang

Shuangshuang Li

Huanhua Luo

Abstract

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and fun...

Subject

Cancer research

Metastasis

Macrophage polarization

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