Radiosensitizing effect of MEK-inhibition in glioblastoma in vitro and in vivo

Houweling, Megan; Kulsoom Abdul, U.; G. Brahm, Cyrillo; Lagerweij, Tonny; Heukelom, S.; W. Koken, Phil; J. Honeywell, Richard; E. Wedekind, Laurine; J. Peters, Godefridus; M.W. Verheul, Henk; Sminia, Peter; P. Noske, David; Würdinger, Tom; A. Westerman, Bart

doi:10.21203/rs.3.rs-2177929/v1

Public

Radiosensitizing effect of MEK-inhibition in glioblastoma in vitro and in vivo

Published in Research Square • Oct 21, 2022

Authors:

Megan Houweling

U. Kulsoom Abdul

Cyrillo G. Brahm

Abstract

Abstract Glioblastoma (GBM) is an incurable cancer type. New therapeutic options are investigated, including targeting the mitogen-activated protein kinase (MAPK) pathway using MEK-inhibitors as radiosensitizers. In this study, we investigated whether MEK-inhibition via PD0325901 leads to radiosensi...

Subject

In vivo

In vitro

MEK inhibitor

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