Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19

Naggie, Susanna; R. Boulware, David; J. Lindsell, Christopher; G. Stewart, Thomas; Gentile, Nina; P. Collins, Sean; W. McCarthy, Matthew; Jayaweera, Dushyantha; Castro, Mario; Sulkowski, Mark; M. McTigue, Kathleen; Thicklin, Florence; Michael Felker, G.; A. Ginde, Adit; T. Bramante, Carolyn; Slandzicki, Alex; Gabriel, Ahab; Shah, Nirav; Lenert, Leslie; E. Dunsmore, Sarah; J. Adam, Stacey; DeLong, Allison; J. Hanna, George; Remaly, April; Wilder, Rhonda; Wilson, Sybil; Shenkman, Elizabeth; F. Hernandez, Adrian; COVID-19 Therapeutic Interventions and Vaccines (ACTIV-6) Study Group and Investigators, Accelerating; Vincent, William; Vincent, Raina; Bianchi, Ray; Premas, Jen; Cordero-Loperena, Diana; M. Rivera, E.; Gupta, Madhu; Karawan, Greg; Ziomek, Carey; Arena, Joseph; DeAlmeida, Sonaly; Ramin, Soroush; Nataraj, Jaya; K. Paasche‐Orlow, Michael; Henault, Lori; Waite, Katie; Miller, David; Brounce, Ginger; George-Adebayo, Constance; Adebayo, Adeolu; Wallan, Jessica; Slandzicki, Alex; Vogel, Claudia; Munoz, Sebastian; Kavtaradze, David; Watson, Cassandra; Singleton, David; Rivon, Maria; Sevier, Amanda; Del Pilar, Arnold; Spangler, Amber; Rao, Sohail; Cantu, Luis; Krishna, Arvind; Evans, Kathy; Falkner, Tylene; Kerr, Brandi; Spees, Robert; Marta, Mailyn; Michael Felker, G.; Harrington, Amanda; J Dolor, Rowena; Frazier, Madison; Vergara, Lorraine; Wilson, Jessica; Burruss, Valencia; Hurst, Terri; Ofotokun, Igho; Bristow, Laurel; Prabhu, Rajesh; Klicka, Krystal; Lightfeather, Amber; James, Vicki; Rogers, Marcella; Parihar, Pradeep; Torress, De'Ambra; Oragwu, Chukwuemeka; Oguego, Ngozi; Pillai, Rajesh; Juma, Mustafa; Gabriel, Ahab; Ghaly, Emad; Al-Haddadin, Dafer; Ramirez, Courtney; Hassanien, Gammal; Ismail, Samah; Meltzer, Andrew; Moran, Seamus; Brehaut, Scott; Roche, Angelina; Mehta, Manisha; Koppinger, Nicole; Baez, Jose; Pagan, Ivone; Abdelsayed, Dallal; Aziz, Mina; A. Robinson, Philip; Nguyen, Julie; Pardue, Victoria; Hammons, Llisa; Ruiz-Unger, Juan; Gonzalez, Susan; Reyes, Lionel; J. Cienki, John; Jimenez, Gisselle; B. Cohen, Jonathan; Wong, Matthew; Yuan, Ying; Szeto, Jeremy; Sulkowski, Mark; Stelmash, Lauren; Amon, Arch; Haight, Daniel; Lamb, Deryl; Harper, Amron; Pyram-Bernard, Nancy; Quintero, Arlen; Adhami, Eftim; Maria, Josette; Paudel, Diksha; Raymond, Oksana; Summers, Jeffrey; Turner, Tammy; Lenert, Leslie; Gallegos, Sam; Ann Szwast, Elizabeth; Abdulghani, Ahsan; Vasoya, Pravin; Miller, Conrad; Wiley, Hawa; Shah, Nirav; Klein, Tovah; Castex, Julie; Feliciano, Phillip; Olivo, Jacqueline; Ghaly, Marian; Javed, Zainub; Nawrocki, Alexandra; G. Vecchiarelli, Anthony; Vigil, Nikki; Cherukuri, Vijaya; Burden, Erica; Linn, Dawn; Fisher, Laura; K. Patel, Vijay; Patel, Praksha; Patel, Yuti; Ellison, Leonard; Harrison, Jeffrey; Shah, Binod; Shah, Sugata; Singh, Upinder; Donahue, Julia; Jazayeri, Yasmin; Gupta, Anita; Chandrasekar, N; Moritz, Beth; Fortt, Tabitha; Fortt, Anisa; Jones-Ince, Ingrid; McKee, Alix; Schattinger, Christy; Wilson, Jason; Farlow, Brenda; Gentile, Nina; Finlaw, Lillian; Richwine, Randall; Williams, Tearani; Paizer, Penny; Carson, Lisa; A. Michelson, Edward; Austin, Danielle; Khetpal, Sangeeta; Cantrell, Tiffany; Franklin, Drew; Marshall, Karissa; Mahadevan, Arvind; Rosequist, Madelyn; Gnoni, Martin; Daffner, Crystal; VandeWeerd, Carla; Roberts, Mitchell; D'Andrea, Mark; C. Lim, Stephen; Swink, Wayne; V. Powers‐Fletcher, Margaret; Mukunzi, Sylvere; Shenkman, Elizabeth; Hensley, Jamie; Manning, Brittney; Isache, Carmen; Bowman, Jennifer; Callaghan-Brown, Angelique; Scott, Taylor; Schwasinger‐Schmidt, Tiffany; Cornejo, Ashlie; Jayaweera, Dushyantha; Almanzar, Maria; Ginsburg, Letty; Hajaz, Americo; T. Bramante, Carolyn; K. Robinson, Matthew; Seithel, Michelle; Sekikawa, Akira; Klawson, Emily; Ostrosky, Luis; Umana, Virginia; F. Patterson, Thomas; Tragus, Robin; Jackson, Patrick; Hallowell, Caroline; M. Haughey, Heather; Vaidya-Tank, Bhavna; Gould, Cameron; Goyal, Parul; Gatewood, Carly; Williamson, John; M. Seagle, Hannah; W. McCarthy, Matthew; Salsgiver, Elizabeth; Armas, Eddie; Cheng, Jhonsai; Huerta, Priscilla; Garcia‐Diaz, Julia; Aamodt, David; Ayers, JaMario; Collins, Jess; Graves, John; Grindstaff, James; E. Harrell, Frank; Lai, Jessica; Lopez, Itzel; Marlin, Jessica; Merkel, Alyssa; Nwosu, Sam; Obregon, Savannah; Orozco, Dirk; Perez-Torres, Yoli; Prato, Nelson; Ratcliff, Colleen; Rhode, Max; L. Rothman, Russell; Shirey-Rice, Jana; Vermillion, Krista; Tan, Hsi-Nien; Tregoning, Seibert; Vance, Meghan; Vongsamphanh, Amber; Weir, Maria; M. Zaleski, Nicole

doi:10.1001/jama.2022.18590

Public

Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19

Published in JAMA • Oct 21, 2022

Authors:

Susanna Naggie

David R. Boulware

Christopher J. Lindsell

Abstract

Importance: The effectiveness of ivermectin to shorten symptom duration or prevent hospitalization among outpatients in the US with mild to moderate symptomatic COVID-19 is unknown. Objective: To evaluate the efficacy of ivermectin, 400 μg/kg, daily for 3 days compared with placebo for the treatment...

Subject

Medicine

Ivermectin

Coronavirus disease 2019 (COVID-19)

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