Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder

Kumano, Hiraku; Nobukawa, Sou; Shirama, Aya; Takahashi, Tetsuya; Takeda, Toshinobu; Ohta, Haruhisa; Kikuchi, Mitsuru; Iwanami, Akira; Kato, Nobumasa; Toda, Shigenobu

doi:10.1162/neco_a_01545

Public

Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder

Published in Neural Computation • Oct 25, 2022

Authors:

Hiraku Kumano

Sou Nobukawa

Aya Shirama

Abstract

Locus coeruleus (LC) overactivity, especially in the right hemisphere, is a recognized pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and may be related to inattention. LC activity synchronizes with the kinetics of the pupil diameter and reflects neural activity related to cognit...

Subject

Pupil

Psychology

Locus coeruleus

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