Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

Boudry, Augustin; Darmon, Sasha; Duployez, Nicolas; Figeac, Martin; Geffroy, Sandrine; Bucci, Maxime; Celli-Lebras, Karine; Duchmann, Matthieu; Joudinaud, Romane; Fenwarth, Laurène; Nibourel, Olivier; Goursaud, Laure; Itzykson, Raphael; Dombret, Hervé; Hunault, Mathilde; Preudhomme, Claude; Salson, Mikaël

doi:10.1186/s12859-022-04983-6

Public

Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

Shared by NobleBlocks on Oct 28, 2022 • 12:00 AM UTC

Authors:

Augustin Boudry

Sasha Darmon

Nicolas Duployez

Abstract

Abstract Background Internal tandem duplications in the FLT3 gene, termed FLT3 -ITDs, are useful molecular markers in acute myeloid leukemia (AML) for patient risk stratification and follow-up. FLT3 -ITDs are increasingly screened through high-throughput sequencing (HTS) raising the need for robust ...

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