Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

Kong, Weili; Montaño, Mauricio; J. Corley, Michael; Helmy, Ekram; Kobayashi, Hirofumi; Kinisu, Martin; K. Suryawanshi, Rahul; Luo, Xiaoyu; A. Royer, Löıc; R. Roan, Nadia; Ott, Mélanie; C. Ndhlovu, Lishomwa; C. Greene, Warner

doi:10.1128/mbio.02308-22

Public

Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

Published in mBio • Oct 31, 2022

Authors:

Weili Kong

Mauricio Montaño

Michael J. Corley

Abstract

SARS-CoV-2 infection primarily targets the lung but may also damage other organs, including the brain, heart, kidney, and intestine. Central nervous system (CNS) pathologies include loss of smell and taste, headache, delirium, acute psychosis, seizures, and stroke. Pathological loss of gray matter o...

Subject

Astrogliosis

Inflammation

Astrocyte

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