Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

M. Goodwin, Guy; T. Aaronson, Scott; Alvarez, Oscar; C. Arden, Peter; Baker, Annie; Bennett, James; Bird, Catherine; E. Blom, Renske; Brennan, Christine; Brusch, Donna; Burke, Lisa; Campbell‐Coker, Kete; Carhart‐Harris, Robin; Cattell, Joseph; Daniel, Aster; DeBattista, Charles; W. Dunlop, Boadie; Eisen, Katherine; Feifel, David; Forbes, MacKenzie; M. Haumann, Hannah; J. Hellerstein, David; I. Hoppe, Astrid; Ishrat Husain, Muhammad; A. Jelen, Luke; Kamphuis, Jeanine; Kawasaki, Julie; R. Kelly, John; E. Key, Richard; Kishon, Ronit; Knatz Peck, Stéphanie; Knight, Gemma; H.B. Koolen, Martijn; Lean, Melanie; Wentzer Licht, Rasmus; L. Maples‐Keller, Jessica; Mars, Jan; Marwood, Lindsey; McElhiney, Martin; Miller, Tammy; Mirow, Arvin; Mistry, Sunil; Mletzko, Tanja; N. Modlin, Liam; Ernst Nielsen, René; M. Nielson, Elizabeth; R. Offerhaus, Sjoerd; O’Keane, Veronica; Páleníček, Tomáš; Printz, David; C. Rademaker, Marleen; van Reemst, Aumer; Reinholdt, Frederick; Repantis, Dimitris; Rucker, James; Rudow, Samuel; Ruffell, Simon; John Rush, A.; A. Schoevers, Robert; Seynaeve, Mathieu; Shao, Samantha; C. Soares, Jair; Somers, Metten; C. Stansfield, S.; Sterling, Diane; Strockis, Aaron; Tsai, Joyce; Visser, Lucy; Wahba, Mourad; P. Williams, Samuel; H. Young, Allan; Ywema, Paula; Zisook, Sidney; Malievskaia, Ekaterina

doi:10.1056/nejmoa2206443

Public

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

Published in New England Journal of Medicine • Nov 2, 2022

Authors:

Guy M. Goodwin

Scott T. Aaronson

Oscar Alvarez

Abstract

BACKGROUND: Psilocybin is being studied for use in treatment-resistant depression. METHODS: In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant depression to receive a single dose of a proprietary, synthetic formulation of psilocybin at a dose of 25 mg, 10 mg, or...

Subject

Psilocybin

Depression (economics)

Hallucinogen

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