Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

R. Kalra, Paul; G.F. Cleland, John; C. Petrie, Mark; Thomson, Elizabeth; A. Kalra, Philip; Squire, Iain; Ahmed, Fozia; Al‐Mohammad, Abdallah; J. Cowburn, Peter; W X Foley, Paul; J Graham, Fraser; G. Japp, Alan; Lane, Rebecca; N. Lang, Ninian; Ludman, Andrew; C. Macdougall, Iain; Pellicori, Pierpaolo; Ray, Robin; Robertson, Michele; Seed, Alison; Ford, Ian; R. Kalra, Paul; G.F. Cleland, John; C. Petrie, Mark; Thomson, Elizabeth; A. Kalra, Philip; Squire, Iain; Ahmed, Fozia; Al‐Mohammad, Abdallah; J. Cowburn, Peter; W X Foley, Paul; J Graham, Fraser; G. Japp, Alan; Lane, Rebecca; N. Lang, Ninian; Ludman, Andrew; C. Macdougall, Iain; Pellicori, Pierpaolo; Ray, Robin; Robertson, Michele; Seed, Alison; Ford, Ian; A. Boon, Nicholas; Amoils, Shannon; Chapman, Callum; G Diness, Thomas; McMurray, John; Mindham, Richard; Sandu, Pamela; Christian Strom, Claes; Travers, Maureen; Wilcox, Robert; D. Struthers, Allan; B. Mark, Patrick; J. Weir, Christopher; Cowan, Elena; Turner, Charlotte; Austin, Rosalynn; Rogers, Paula; Chandrasekaran, Badri; Fraile, E; Kyeremeh, Lynsey; McGregor, Lorraine; Osmanska, Joanna; Meyer, Barbara; Ahmad, Faheem; Fisher, Jude; Summersgill, Christina; Adeniji, Katarzyna; Chinnadurai, Rajkumar; Massimo, Lisa; S. Hardman, Clare; Sykes, Daisy; Frank, Sarah; Smith, Simon; Anwar, Mohamed; Whittington, Beth; Sookhoo, Vennessa; Lyons, Sinéad; Middle, Janet; Housley, Kay; L. Clark, Andrew; Bulemfu, Jeanne; Critoph, Christopher; Chong, Victor; J. Wood, Stephen; R. Szwejkowski, Benjamin; C. Lang, Chim; Duff, Jackie; M. MacDonald, Susan; Schiff, Rebekah; Donnelly, Patrick; Nageh, Thuraia; Kunhunny, Swapna; S. Gardner, Roy; McAdam, Marion; McPherson, Elizabeth; Banerjee, Prithwish; Sear, Eleanor; Edwards, Nigel; Glover, Jason; Murphy, Clare; Cooke, Justin; Spencer, Charles; Francis, Mark; Matthews, Iain; McKie, Hayley; Marshall, Andrew; Large, Janet; Stratford, Jenny; Clifford, Piers; J. Boos, Christopher; J. Keeling, Philip; Hughes, Debbie; Wong, Aaron; J. Jones, Deborah; James, Alex; Williams, Rhys; J Leslie, Stephen; Finlayson, Jim; Hannah, Andrew; Campbell, Philip; Walsh, John; Quinn, Jane; Piper, Susan; Patale, Sheetal; Gupta, Preeti; Sim, Victor; Knibbs, Lucy; Lyons, Kristopher; Dixon, Lana; J. Petrie, Colin; Wong, Yuk-ki; Labinjoh, Catherine; Duckett, Simon; J. Massey, Ian; Oluwasefunmi Savage, Henry; Matias, Sofia; Ramirez, Jonaifah; Manisty, Charlotte; Hussain, Ifza; Sankaranarayanan, Rajiv; Davis, Gershan; McClure, Samuel; Baxter, John; Wicks, Eleanor; Sobolewska, Jolanta; D. Murphy, Jerry; Elzayat, Ahmed; Cooke, Alastair; Wright, Jay; G. Williams, Simon; Muthumala, Amal; S Chaggar, Parminder; Webber, Sue; Ellis, Gethin; Welch, Mandie; Bulugahapitiya, Sudantha; Jackson, Thomas; Pakrashi, Tapesh; Bakhai, Ameet; Krishnamurthy, Vinodh; Gamma, Reto; Ellery, Susan; H. Jenkins, Geraint; Thomas, Gladdys; K. Nightingale, Angus; Greenlaw, Nicola; Wetherall, Kirsty; Clarke, Ross; Graham, Christopher; Kean, Sharon; C. Stevenson, A.; S. Wilson, Robbie; C. Boyle, Sarah; B. McHugh, John; Hall, Lisa; Woollard, Joanne; Brunton, Claire; Dinnett, Eleanor; Reid, Amanda; Howe, Serena; Nicholls, Jill; Cunnington, Anna; Douglas, Elizabeth; Fegen, Margaret; V. Jones, Marc; McGowan, Sheila; Ross, Barbara; Surtees, Pamela; Stuart, Debra

doi:10.1016/s0140-6736(22)02083-9

Public

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

Published in The Lancet • Nov 5, 2022

Authors:

Paul R. Kalra

John G.F. Cleland

Mark C. Petrie

Abstract

BACKGROUND: For patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric carboxymaltose administration improves quality of life and exercise capacity in the short-term and reduces hospital admissions for heart failure up to 1 year. We aimed to e...

Subject

Medicine

Heart failure

Clinical endpoint

Research Assistant

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