Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment

Luo, Han; Xia, Xuyang; Huang, Li‐Bin; An, Hyunsu; Cao, Minyuan; Dae Kim, Gyeong; Chen, Hai‐Ning; Zhang, Weihan; Shu, Yang; Kong, Xiangyu; Ren, Zhixiang; Li, Peiheng; Liu, Yang; Tang, Huairong; Sun, Ronghao; Li, Chao; Bai, Bing; Jia, Weiguo; Liu, Yi; Zhang, Wei; Yang, Li; Peng, Yong; Dai, Lunzhi; Hu, Hongbo; Jiang, Yong; Hu, Yiguo; Zhu, Jingqiang; Jiang, Hong; Li, Zhihui; Caulı́n, Carlos; Park, Jihwan; Xu, Heng

doi:10.1038/s41467-022-34395-2

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Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment

Published in Nature Communications • Nov 4, 2022

Authors:

Han Luo

Xuyang Xia

Li‐Bin Huang

Abstract

Abstract Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different cancer types. Here, we perform pan-cancer analysis on 226 samples...

Subject

Cancer-Associated Fibroblasts

Tumor microenvironment

Cancer

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