MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

L. Kaufmann, Tom; Petković, Marina; B.K. Watkins, Thomas; Colliver, Emma; Laskina, Sofya; Thapa, Nisha; Conterno Minussi, Darlan; E. Navin, Nicholas; Swanton, Charles; Van Loo, Peter; Haase, Kerstin; Tarabichi, Maxime; F. Schwarz, Roland

doi:10.1186/s13059-022-02794-9

Public

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Published in Genome biology • Nov 14, 2022

Authors:

Tom L. Kaufmann

Marina Petković

Thomas B.K. Watkins

Abstract

Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-speci...

Subject

Biology

Phylogenetic tree

Genome

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