Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma

M. Liau, Linda; Ashkan, Keyoumars; Brem, Steven; Campian, Jian; Trusheim, John; M. Iwamoto, Fábio; D. Tran, David; Ansstas, George; Cobbs, Charles; Heth, Jason; Salacz, Michael; D. D’Andre, Stacy; Aiken, Robert; A. Moshel, Yaron; Yeon Nam, Joo; Pillainayagam, Clement; A. Wagner, Stephanie; A. Walter, Kevin; Chaudhary, Rekha; Goldlust, Samuel; Lee, Ian; A. Bota, Daniela; Elinzano, Heinrich; Grewal, Jai; O. Lillehei, Kevin; Mikkelsen, Tom; Walbert, Tobias; R. Abram, Steven; Brenner, Andrew; G. Ewend, Matthew; Khagi, Simon; Lovick, Darren; Portnow, Jana; Kim, Lyndon; G. Loudon, William; Martinez, Nina; C. Thompson, Reid; Avigan, David; Fink, Karen; J. Geoffroy, Francois; Giglio, Pierre; Gligich, Oleg; Krex, Dietmar; Lindhorst, Scott; Lutzky, Jose; Meisel, Hans-Joerg; Nadji‐Ohl, Minou; Sanchin, Lhagva; E. Sloan, Andrew; P. Taylor, Lynne; K. Wu, Julian; Dunbar, Erin; B. Etame, Arnold; Kesari, Santosh; Mathieu, David; Piccioni, David; S. Baskin, David; Lacroix, Michel; May, Sven-Axel; New, Pamela; Pluard, Timothy; A. Toms, Steven; Tse, Victor; Peak, Scott; L. Villano, John; Battiste, James; Mulholland, Paul; Pearlman, Michael; Petrecca, Kevin; Schulder, Michael; M. Prins, Robert; L. Boynton, Alton; L. Bosch, Marnix

doi:10.1001/jamaoncol.2022.5370

Public

Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma

Published in JAMA Oncology • Nov 17, 2022

Authors:

Linda M. Liau

Keyoumars Ashkan

Steven Brem

Abstract

Importance: Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed. Objective: To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among p...

Subject

Medicine

Temozolomide

Internal medicine

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