A multicenter study of clinical impact of variant of uncertain significance reclassification in breast, ovarian and colorectal cancer susceptibility genes

Makhnoon, Sukh; Levin, Brooke; Ensinger, Megan; Mattie, Kristin; J. Volk, Robert; Zhao, Zhongming; R. Mendoza, Tito; Shete, Sanjay; Samiian, Laila; Grana, Generosa; V. Grainger, Andrew; Arun, Banu; H. Shirts, Brian; K. Peterson, Susan

doi:10.1002/cam4.5202

Public

A multicenter study of clinical impact of variant of uncertain significance reclassification in breast, ovarian and colorectal cancer susceptibility genes

Published in Cancer Medicine • Nov 24, 2022

Authors:

Sukh Makhnoon

Brooke Levin

Megan Ensinger

Abstract

BACKGROUND: Clinical interpretation of genetic test results is complicated by variants of uncertain significance (VUS) that have an unknown impact on health but can be clarified through reclassification. There is little empirical evidence regarding VUS reclassification in oncology care settings, inc...

Subject

Colorectal cancer

Ovarian cancer

Oncology

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