Targeted xCT‐mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti‐PD‐1/L1 Response

Tang, Bufu; Zhu, Jinyu; Wang, Yajie; Chen, Weiqian; Fang, Shiji; Mao, Weiyang; Xu, Ziwei; Yang, Yang; Weng, Qiaoyou; Zhao, Zhongwei; Chen, Minjiang; Ji, Jiansong

doi:10.1002/advs.202203973

Public

Targeted xCT‐mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti‐PD‐1/L1 Response

Published in Advanced Science • Nov 28, 2022

Authors:

Bufu Tang

Jinyu Zhu

Yajie Wang

Abstract

Tumor-associated macrophages (TAMs) play an essential role in tumor progression, metastasis, and antitumor immunity. Ferroptosis has attracted extensive attention for its lethal effect on tumor cells, but the role of ferroptosis in TAMs and its impact on tumor progression have not been clearly defin...

Subject

Cancer research

Macrophage polarization

Tumor microenvironment

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