Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.

L H Webster, Andrew; A Sanders, Mathijs; Patel, Krupa; Dietrich, Ralf; J Noonan, Raymond; P Lach, Francis; R White, Ryan; Goldfarb, Audrey; Hadi, Kevin; M Edwards, Matthew; X Donovan, Frank; M Hoogenboezem, Remco; Jung, Moonjung; Sridhar, Sunandini; F Wiley, Tom; Fedrigo, Olivier; Tian, Huasong; Rosiene, Joel; Heineman, Thomas; A Kennedy, Jennifer; Bean, Lorenzo; O Rosti, Rasim; Tryon, Rebecca; Gonzalez, Ashlyn-Maree; Rosenberg, Allana; Luo, Ji-Dung; S Carroll, Thomas; Shroff, Sanjana; Beaumont, Michael; Velleuer, Eunike; C Rastatter, Jeff; I Wells, Susanne; Surrallés, Jordi; Bagby, Grover; L MacMillan, Margaret; E Wagner, John; Cancio, Maria; Boulad, Farid; Scognamiglio, Theresa; Vaughan, Roger; G Beaumont, Kristin; Koren, Amnon; Imielinski, Marcin; C Chandrasekharappa, Settara; D Auerbach, Arleen; Singh, Bhuvanesh; I Kutler, David; J Campbell, Peter; Smogorzewska, Agata

doi:10.1038/s41586-022-05253-4

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Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.

Shared by NobleBlocks on Dec 1, 2022 • 12:00 AM UTC

Authors:

Andrew L H Webster

Mathijs A Sanders

Krupa Patel

Abstract

Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1-3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4-7. Individuals with FA are hundreds to thousands fo...

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