Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes

Higgins, Kendall; A. Moore, Bret; Berberovic, Zorana; A. Adissu, Hibret; Eskandarian, Mohammad; M. Flenniken, Ann; Shao, Andy; M. Imai, Denise; Clary, Dave; Lanoue, Louise; Newbigging, Susan; M. J. Nutter, Lauryl; J. Adams, David; Bosch, Fátima; E. Braun, Robert; D. M. Brown, Steve; E. Dickinson, Mary; S. Dobbie, Michael; Flicek, Paul; Gao, Xiang; Galande, Sanjeev; Grobler, Anne; D. Heaney, Jason; Hérault, Yann; Hrabě de Angelis, Martin; Chin, Hsian‐Jean; Mammano, Fabio; Qin, Chuan; Shiroishi, Toshihiko; Sedláček, Radislav; Kyung Seong, Je; Xu, Ying; L. Beaudet, Arthur; Braun, Bob; A. Karp, Natasha; Mallon, Ann‐Marie; F. Meehan, Terrence; Obata, Yuichi; Parkinson, Helen; Smedley, Damian; P. Tocchini‐Valentini, Glauco; Wells, Sara; C. Kent Lloyd, K.; McKerlie, Colin; Moshiri, Ala

doi:10.1038/s41598-022-19710-7

Public

Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes

Published in Scientific Reports • Dec 1, 2022

Authors:

Kendall Higgins

Bret A. Moore

Zorana Berberovic

Abstract

We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes. We first screened for phenotypes in mouse lines with both ocular and renal or reproductive trait abnormalities. The STRING protein intera...

Subject

Ciliopathy

Ciliopathies

Biology

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