Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

G. Aragam, Krishna; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; N. Wolford, Brooke; Atri, Deepak; Weeks, E.; Wang, Minxian; Hindy, George; Zhou, Wei; Grace, Christopher; Roselli, Carolina; Marston, Nicholas; Kamanu, Frederick; Surakka, Ida; Muñoz Venegas, Loreto; Sherliker, Paul; Koyama, Satoshi; Ishigaki, Kazuyoshi; Olav Åsvold, Bjørn; R. Brown, Michael; Brumpton, Ben; S. de Vries, Paul; Giannakopoulou, Olga; Giardoglou, Tota; F. Guðbjartsson, Daníel; Güldener, Ulrich; M. Ijlal Haider, Syed; Helgadóttir, Anna; Ibrahim, M; Kastrati, Adnan; Kessler, Thorsten; Kyriakou, Theodosios; Konopka, Tomasz; Li, Ling; Ma, Lijiang; Meitinger, Thomas; Mucha, Sören; Munz, Matthias; Murgia, Federico; B. Nielsen, Jonas; M. Nöthen, Markus; Pang, Shichao; Reinberger, Tobias; R. Schnitzler, Gavin; Smedley, Damian; Þorleifsson, Guðmar; von Scheidt, Moritz; C. Ulirsch, Jacob; Japan, Biobank; , EPIC-CVD; Danesh, John; O. Arnar, Davíð; P. Burtt, Noël; C. Costanzo, Maria; Flannick, Jason; Ito, Kaoru; Jang, Dongkeun; Kamatani, Yoichiro; V. Khera, Amit; Komuro, Issei; J. Kullo, Iftikhar; A. Lotta, Luca; P. Nelson, Christopher; Roberts, Robert; Þorgeirsson, Guðmundur; Þorsteinsdóttir, Unnur; R. Webb, Tom; Baras, Aris; Björkegren, Johan; Boerwinkle, Eric; Dedoussis, George; Hólm, Hilma; Hveem, Kristian; Melander, Olle; C. Morrison, Alanna; Orho‐Melander, Marju; S. Rallidis, Lοukianos; Ruusalepp, Arno; S. Sabatine, Marc; Stefánsson, Kāri; Zalloua, Pierre; T. Ellinor, Patrick; Farrall, Martin; Danesh, John; T. Ruff, Christian; K. Finucane, Hilary; C. Hopewell, Jemma; Clarke, Robert; M. Gupta, Rajat; Erdmann, Jeanette; J. Samani, Nilesh; Schunkert, Heribert; Watkins, Hugh; J. Willer, Cristen; Deloukas, Panos; Kathiresan, Sekar; S. Butterworth, Adam; S. de Vries, Paul; von Scheidt, Moritz

doi:10.1038/s41588-022-01233-6

Public

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Published in Nature Genetics • Dec 1, 2022

Authors:

Krishna G. Aragam

Tao Jiang

Anuj Goel

Abstract

The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly Europea...

Subject

Biology

Genome-wide association study

Coronary artery disease

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