FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Brevini, Teresa; Maes, Mailis; J. Webb, Gwilym; V. John, Binu; Fuchs, Claudia; Buescher, Gustav; Wang, Lu; Griffiths, C.; L. Brown, Marnie; E. Scott, William; Pereyra-Gerber, Pehuén; Gelson, William; Brown, Stephanie; Dillon, Scott; Muraro, Daniele; Sharp, Joanne; Neary, Megan; Box, Helen; Tatham, Lee; P. Stewart, James; Curley, Paul; Pertinez, Henry; Forrest, Sally; Mlčochová, Petra; Varankar, Sagar; Darvish-Damavandi, Mahnaz; Mulcahy, Victoria; E. Kuc, Rhoda; Williams, Thomas; A. Heslop, James; Rossetti, Davide; Tysoe, Olivia; Galanakis, Vasileios; Vilà‐González, Marta; W. M. Crozier, Thomas; Bargehr, Johannes; Sinha, Sanjay; Upponi, Sara; Fear, Corrina; Swift, Lisa; Saeb‐Parsy, Kourosh; Davies, Susan; Wester, Axel; Hagström, Hannes; Melum, Espen; Clements, Darran; Humphreys, Peter; Herriott, Jo; Kijak, Edyta; Cox, Helen; Bramwell, Chloe; Valentijn, Anthony; J. R. Illingworth, Christopher; Dahman, Bassam; Bastaich, Dustin; Ferreira, Raphaella; Marjot, Thomas; Barnes, Eleanor; M. Moon, Andrew; Sidney Barritt, A.; K. Gupta, Ravindra; Baker, Stephen; P. Davenport, Anthony; Corbett, Gareth; G. Gorgoulis, Vassilis; J. A. Buczacki, Simon; Lee, Joo‐Hyeon; J. Matheson, Nicholas; Trauner, Michael; J. Fisher, Andrew; Gibbs, Paul; J. Butler, Andrew; J.E. Watson, Christopher; Mells, George; Dougan, Gordon; Owen, Andrew; W. Lohse, Ansgar; Vallier, Ludovic; Sampaziotis, Fotios

doi:10.1038/s41586-022-05594-0

Public

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Published in Nature • Dec 5, 2022

Authors:

Teresa Brevini

Mailis Maes

Gwilym J. Webb

Abstract

. However, the mechanisms that control the expression of ACE2 remain unclear. Here we show that the farnesoid X receptor (FXR) is a direct regulator of ACE2 transcription in several tissues affected by COVID-19, including the gastrointestinal and respiratory systems. We then use the over-the-counter...

Subject

Downregulation and upregulation

Ursodeoxycholic acid

Farnesoid X receptor

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