Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression

A. Trzaskalski, Natasha; Vulesevic, Branka; Nguyen, My-Anh; Jeraj, Natasha; Fadzeyeva, Evgenia; M. Morrow, Nadya; A.A. Locatelli, Cassandra; M. Travis, Nicole; A. Hanson, Antonio; R.C. Nunes, Julia; O’Dwyer, Conor; N. van der Veen, Jelske; Lorenzen‐Schmidt, Ilka; Seymour, Rick; M. Pulente, Serena; C. Clément, Andrew; M. Crawley, Angela; L. Jacobs, René; Doyle, Mary-Anne; Cooper, Curtis; Kim, Kyoung-Han; D. Fullerton, Morgan; E. Mulvihill, Erin

doi:10.1172/jci.insight.154314

Public

Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression

Published in JCI Insight • Dec 6, 2022

Authors:

Natasha A. Trzaskalski

Branka Vulesevic

My-Anh Nguyen

Abstract

Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not TEK receptor tyrosine kinase-positive endothelial...

Subject

Internal medicine

Endocrinology

Insulin resistance

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