Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma

W. Rohaan, Maartje; Holz Borch, Troels; H. van den Berg, Joost; Met, Özcan; Kessels, Rob; H. Geukes Foppen, Marnix; Stoltenborg Granhøj, Joachim; Nuijen, Bastiaan; M. Nijenhuis, Cynthia; Jedema, Inge; van Zon, Maaike; Scheij, Saskia; H. Beijnen, Jos; Hansen, Marten; Voermans, Carlijn; Noringriis, I.M.; J. Monberg, Tine; Boedker Holmstroem, Rikke; D.V. Wever, Lidwina; van Dijk, M.; G. Grijpink-Ongering, Lindsay; H.M. Valkenet, Ludy; Torres Acosta, A.; Karger, Matthias; S.W. Borgers, Jessica; M.T. ten Ham, Renske; P. Retèl, Valesca; H. van Harten, Wim; Lalezari, Ferry; van Tinteren, Harm; A.M. van der Veldt, Astrid; A.P. Hospers, Geke; A. M. Stevense‐den Boer, Marion; P.M. Suijkerbuijk, Karijn; J.B. Aarts, Maureen; Piersma, Djura; J.M. van den Eertwegh, Alfons; B. de Groot, Jan‐Willem; Vreugdenhil, Gerard; Kapiteijn, Ellen; J. Boers‐Sonderen, Marye; Edward Fiets, W.; W.P.J. van den Berkmortel, Franchette; Ellebæk, Eva; Rosenkrantz Hölmich, Lisbet; C. J. van Akkooi, Alexander; J. van Houdt, Winan; W.J.M. Wouters, Michel; V. van Thienen, Johannes; U. Blank, Christian; Meerveld-Eggink, A.; Klobuch, Sebastian; Wilgenhof, Sofie; N. Schumacher, Ton; Donia, Marco; Marie Svane, Inge; B.A.G. Haanen, John

doi:10.1056/nejmoa2210233

Public

Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma

Published in New England Journal of Medicine • Dec 7, 2022

Authors:

Maartje W. Rohaan

Troels Holz Borch

Joost H. van den Berg

Abstract

BACKGROUND: Immune checkpoint inhibitors and targeted therapies have dramatically improved outcomes in patients with advanced melanoma, but approximately half these patients will not have a durable benefit. Phase 1-2 trials of adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) have sho...

Subject

Ipilimumab

Melanoma

Tumor-infiltrating lymphocytes

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