Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T-cell recognition epitopes

Muik, Alexander; Gaby Lui, Bonny; Diao, Huitian; Fu, Yunguan; Bacher, Maren; Toker, Aras; Grosser, Jessica; Ozhelvaci, Orkun; Grikscheit, Katharina; Hoehl, Sebastian; Kohmer, Niko; Lustig, Yaniv; Regev‐Yochay, Gili; Ciesek, Sandra; Beguir, Karim; Poran, Asaf; Türeci, Özlem; Şahin, Uğur

doi:10.1101/2022.12.15.520569

Public

Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T-cell recognition epitopes

Published in bioRxiv (Cold Spring Harbor Laboratory) • Dec 15, 2022

Authors:

Alexander Muik

Bonny Gaby Lui

Huitian Diao

Abstract

Abstract The continued evolution of the SARS-CoV-2 Omicron variant has led to the emergence of numerous sublineages with different patterns of evasion from neutralizing antibodies. We investigated neutralizing activity in immune sera from individuals vaccinated with SARS-CoV-2 wild-type spike (S) gl...

Subject

Epitope

Neutralization

Antibody

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