Multimodal chromatin profiling using nanobody-based single-cell CUT&amp;Tag

Bartošovič, Marek; Castelo‐Branco, Gonçalo

doi:10.1038/s41587-022-01535-4

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Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag

Published in Nature Biotechnology • Dec 19, 2022

Authors:

Marek Bartošovič

Gonçalo Castelo‐Branco

Abstract

Probing histone modifications at a single-cell level in thousands of cells has been enabled by technologies such as single-cell CUT&Tag. Here we describe nano-CUT&Tag (nano-CT), which allows simultaneous mapping of up to three epigenomic modalities at single-cell resolution using nanobody-Tn5 fusion...

Subject

Chromatin

Single-cell analysis

Biology

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