The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer

Blanc, Charly; Moktefi, Anissa; Jolly, Ariane; de la Grange, Pierre; Gay, Denise; Nicolaı̈ew, Nathalie; Semprez, Fannie; Maillé, Pascale; Soyeux, Pascale; Firlej, Virginie; Vacherot, Francis; Destouches, Damien; Amiche, Mohamed; Terry, Stéphane; de la Taille, Alexandre; Londoño‐Vallejo, Arturo; Allory, Yves; Delbé, Jean; Hamma‐Kourbali, Yamina

doi:10.1038/s41416-022-02114-9

Public

The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer

Published in British Journal of Cancer • Dec 22, 2022

Authors:

Charly Blanc

Anissa Moktefi

Ariane Jolly

Abstract

BACKGROUND: Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate cancer (PCa) that has become a major challenge in clinics. Understanding the neuroendocrine differentiation (NED) process at the molecular level is therefore critical to define therapeutic strategies that can ...

Subject

Prostate cancer

Cancer research

Neuroendocrine differentiation

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