Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Butler, Christopher; Hobbs, Richard; Gbinigie, Oghenekome; M. Rahman, Najib; Hayward, Gail; Richards, Duncan; Dorward, Jienchi; M. Lowe, David; F. Standing, Joseph; Breuer, Judith; Khoo, Saye; Petrou, Stavros; Hood, Kerenza; S. Nguyen‐Van‐Tam, Jonathan; Patel, Mihir; R. Saville, Benjamin; Marion, Joe; Ogburn, Emma; Allen, Julie; Rutter, Heather; Francis, Nick; Thomas, Nicholas; Evans, Philip; Dobson, Melissa; Madden, Tracie‐Ann; Holmes, Jane; Harris, Victoria; Ee Png, May; Lown, Mark; van Hecke, Oliver; A. Detry, Michelle; Saunders, Christina; Fitzgerald, Mark; Berry, Nicholas; Mwandigha, Lazaro; Galal, Ushma; Mort, Sam; Jani, Bhautesh; Hart, Nigel; Ahmed, Haroon; Butler, Daniel; McKenna, Micheal; Chalk, Jem; Lavallee, Layla; Hadley, Elizabeth; Cureton, Lucy; Benysek, Magdalena; Andersson, Monique; Coates, Maria; Barrett, Sarah; Bateman, Clare; Davies, Jennifer; Raymundo-Wood, Ivy; Ustianowski, Andrew; Carson‐Stevens, Andrew; Yu, Ly‐Mee; Little, Paul; Adom Agyeman, Akosua; Ahmed, Tanveer; Allcock, Damien; Beltran-Martinez, Adrian; E Benedict, Oluseye; C. Bird, Nigel; K. Brennan, Laura; R. Brown, Julianne; P. Burns, Gerard; Butler, Mike; Cheng, Zelda; Danson, Ruth; de Kare-Silver, Nigel; Dhasmana, Devesh; M Dickson, Jon; Engamba, Serge; Fisher, Stacey; Fox, Robin; Frost, Eve; A. Gaunt, Richard; K. Ghosh, Sarit; A Gilkar, Ishtiaq; L. Goodman, Anna; Granier, Steve; Howell, Aleksandra; Hussain, Iqbal; M. Hutchinson, Simon; Imlach, Marie; Irving, Greg; Jacobsen, Nicholas; Kennard, James; Khan, Umar; Knox, Kyle; Krasucki, Christopher; Law, Tom; Lee, Rem; Lester, Nicola; Lewis, David; Lunn, J.A.; I. Mackintosh, Claire; Mathukia, Mehul; S. Moore, Patrick; Morton, Seb; M. Murphy, Daniel; Nally, Rhiannon; Ndukauba, Chinonso; Ogundapo, Olufunto; Okeke, Henry; Patel, Amit; Patel, Kavil; Penfold, Ruth; Poonian, Satveer; Popoola, Olajide; Pora, Alexander; Prasad, Vibhore; Prasad, Rishabh; Razzaq, Omair; Richardson, Scot; Royal, Simon; Safa, Afsana; Sehdev, Satash; Sevenoaks, Tamsin; Shah, Divya; Sheikh, Aadil; L. Short, Vanessa; S Sidhu, Baljinder; Singh, Ivor; Soni, Yusuf; Thalasselis, Chris; Wilson, Pete; Wingfield, David; Wong, Michael; Woodall, Maximillian; Wooding, Nick; Woods, Sharon; Yong, Joanna; Yongblah, Francis; Zafar, Azhar

doi:10.1016/s0140-6736(22)02597-1

Public

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Published in The Lancet • Dec 22, 2022

Authors:

Christopher Butler

Richard Hobbs

Oghenekome Gbinigie

Abstract

BACKGROUND: The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. We aimed to establish whether the addition of molnu...

Subject

Medicine

Randomized controlled trial

Adverse effect

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