Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

Zhang, Zili; Zhou, Haifeng; Ouyang, Xiaohu; Dong, Yalan; Sarapultsev, Alexey; Luo, Shanshan; Hu, Desheng

doi:10.1038/s41392-022-01252-z

Public

Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

Published in Signal Transduction and Targeted Therapy • Dec 23, 2022

Authors:

Zili Zhang

Haifeng Zhou

Xiaohu Ouyang

Abstract

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been endeavored to clarify the molecular mechanism of its activation, its physiological function as a ubiquitously expressed protein,...

Subject

Sting

Mechanism (biology)

Disease

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