ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia

Kreider-Letterman, Gabriel; Castillo, Abel; K. Mahlandt, Eike; Goedhart, Joachim; Rabino, Agustín; M. Goicoechea, Silvia; García‐Mata, Rafael

doi:10.1083/jcb.202207020

Public

ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia

Published in The Journal of Cell Biology • Nov 29, 2022

Authors:

Gabriel Kreider-Letterman

Abel Castillo

Eike K. Mahlandt

Abstract

Invadopodia formation is regulated by Rho GTPases. However, the molecular mechanisms that control Rho GTPase signaling at invadopodia remain poorly understood. Here, we have identified ARHGAP17, a Cdc42-specific RhoGAP, as a key regulator of invadopodia in breast cancer cells and characterized a nov...

Subject

Invadopodia

CDC42

Cell biology

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