Activation of the Alternate Pathway of Human Complement by Rabbit Cells

A.E. Platts‐Mills, Thomas; Ishizaka, Kimishige

doi:10.4049/jimmunol.113.1.348

Public

Activation of the Alternate Pathway of Human Complement by Rabbit Cells

Published in The Journal of Immunology • Jul 1, 1974

Authors:

Thomas A.E. Platts‐Mills

Kimishige Ishizaka

Abstract

Abstract The hemolysis of sheep red blood cells (SRBC) occurs via the classical complement pathway and is blocked by ethylene glycol bis-amino tetraacetate (EGTA). By contrast, fresh normal human serum in EGTA buffer was found to cause >90% hemolysis of unsensitized rabbit red blood cells (RaRBC) at...

Subject

EGTA

Classical complement pathway

Hemolysis

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