IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

V Jovanovic, Dragan; A Di Battista, John; Martel-Pelletier, Johanne; C Jolicoeur, François; He, Yulan; Zhang, Mengkun; Mineau, François; Pelletier, Jean-Pierre

doi:10.4049/jimmunol.160.7.3513

Public

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

Shared by NobleBlocks on Apr 1, 1998 • 12:00 AM UTC

Authors:

Dragan V Jovanovic

John A Di Battista

Johanne Martel-Pelletier

Abstract

Abstract IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As such, we examined the release of proinflammatory mediators by human macrophages in response to recombinant human (rh) IL-17. IL-1β and TNF-α expression and synthesis were up-regulated by rhIL-17 ...

Discussions