CD38+ cell depletion with TAK-079 reduces arthritis in a cynomolgus collagen-induced arthritis (CIA) model

Smithson, Glennda; Zalevsky, Jonathan; Korver, Wouter; Roepcke, Stefan; McLean, Lachy

doi:10.4049/jimmunol.198.supp.127.17

Public

CD38+ cell depletion with TAK-079 reduces arthritis in a cynomolgus collagen-induced arthritis (CIA) model

Published in The Journal of Immunology • May 1, 2017

Authors:

Glennda Smithson

Jonathan Zalevsky

Wouter Korver

Abstract

Abstract TAK-079 is a fully human, cytolytic IgG1 mAb against human CD38. We tested the ability of TAK-079 to treat arthritis using a monkey CIA model with features of symmetrical small joint polyarthritis resembling human RA. Monkeys were injected with bovine collagen type II in complete Freund’s a...

Subject

Medicine

Arthritis

Dexamethasone

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