The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Han, Lu; Wu, Yongxia; Fang, Kun; Sweeney, Sean; K. Roesner, Ulyss; Parrish, Melodie; Patel, Khushbu; Walter, Tom; Piermattei, Julia; J. Trimboli, Anthony; E. Lefler, Julia; Timmers, Cynthia; Yu, Xue‐Zhong; X. Jin, Victor; T. Zimmermann, Michael; Mathison, Angela; Urrutia, Raúl; C. Ostrowski, Michael; Leone, Gustavo

doi:10.1038/s41467-022-34464-6

Public

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Published in Nature Communications • Jan 3, 2023

Authors:

Lu Han

Yongxia Wu

Kun Fang

Abstract

Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the major cellular component. However, the tissue(s) of origin for CAFs remains controversial. Here we determine the tissue o...

Subject

Mesenchyme

Biology

Desmoplasia

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