Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Hashemi, Mehrdad; Etemad, Sara; Rezaei, Sahar; Ziaolhagh, Setayesh; Rajabi, Romina; Rahmanian, Parham; Abdi, Soheila; Khazaei Koohpar, Zeinab; Rafiei, Reihaneh; Raei, Behnaz; Ahmadi, Fatemeh; Salimimoghadam, Shokooh; Reza Aref, Amir; Arad Zandieh, Mohammad; Entezari, Maliheh; Taheriazam, Afshin; Hushmandi, Kiavash

doi:10.1016/j.biopha.2022.114204

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Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Published in Biomedicine & Pharmacotherapy • Jan 4, 2023

Authors:

Mehrdad Hashemi

Sara Etemad

Sahar Rezaei

Abstract

Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due to its sensitive location, surgical resection has high risk and therefore, chemotherapy and radiotherapy are utilized for its treatment. However, chemoresistance and radio-resistance are other problems in GBM t...

Subject

PTEN

PI3K/AKT/mTOR pathway

Protein kinase B

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