Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer

Ozato, Yuki; Kojima, Yasuhiro; Kobayashi, Yuta; Hisamatsu, Yuuichi; Toshima, Takeo; Yonemura, Yusuke; Masuda, Takaaki; Kagawa, Kouichi; Gotô, Yasuhiro; Utou, Mitsuaki; Fukunaga, Mituko; Gamachi, Ayako; Imamura, Kiyomi; Kuze, Yuta; Zenkoh, Junko; Suzuki, Ayako; Niida, Atsushi; Hirose, Haruka; Hayashi, Shuto; Koseki, Jun; Oki, Eiji; Fukuchi, Satoshi; Murakami, Kazunari; Tobo, Taro; Nagayama, Satoshi; Uemura, Mamoru; Sakamoto, Takeharu; Oshima, Masanobu; Doki, Yuichiro�; Eguchi, Hidetoshi; Mori, Masaki; Iwasaki, Takeshi; Oda, Yoshinao; Shibata, Tatsuhiro; Suzuki, Yutaka; Shimamura, Teppei; Mimori, Koshi

doi:10.1016/j.celrep.2022.111929

Public

Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer

Published in Cell Reports • Jan 1, 2023

Authors:

Yuki Ozato

Yasuhiro Kojima

Yuta Kobayashi

Abstract

The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular importance for CRC treatment strategies. To this end, we analyz...

Subject

Stromal cell

Biology

Transcriptome

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!